ArticleKidney international2016
Predicting residual kidney function in hemodialysis patients using serum β-trace protein and β2-microglobulin.
Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Characterization of residual kidney function in chronic hemodialysis patients using plasma metabolomics.Scientific reports · 2026Article
- Continuous beta-2 microglobulin-based clearance highlights superiority of high-Dose HDF over high-flux HD in predicting outcomes.Scientific reports · 2025Article
- A practical approach to implementing incremental haemodialysis.Journal of nephrology · 2024Review
- Residual Kidney Function in Hemodialysis: Its Importance and Contribution to Improved Patient Outcomes.Toxins · 2024Review
- Dialysis for older adults: why should the targets be different?Journal of nephrology · 2024Review
- Predicting solute transfer rate in patients initiating peritoneal dialysis.Journal of nephrology · 2024Article
- Incremental dialysis: review of the literature with pediatric perspective.Pediatric nephrology (Berlin, Germany) · 2024Review
- Delayed Graft Function After Kidney Transplantation: The Role of Residual Diuresis and Waste Products, as Oxalic Acid and Its Precursors.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Choice of the Dialysis Modality: Practical Considerations.Journal of clinical medicine · 2023Review
- Population pharmacokinetics and individualized dosing of vancomycin for critically ill patients receiving continuous renal replacement therapy: the role of residual diuresis.Frontiers in pharmacology · 2023Article
- Incremental and Personalized Hemodialysis Start: A New Standard of Care.Kidney international reports · 2022Article
- Incremental Hemodialysis: What We Know so Far.International journal of nephrology and renovascular disease · 2022Review
- Serum β2-microglobulin as a predictor of residual kidney function in peritoneal dialysis patients.Journal of nephrology · 2021Article
- Effect of GM6001 on the expression of syndecan-1 in rats with acute kidney injury and its protective effect on the kidneys.Experimental and therapeutic medicine · 2020Article
- Article
- Narrative Review of Incremental Hemodialysis.Kidney international reports · 2020Review
- Article
- Predicting Residual Function in Hemodialysis and Hemodiafiltration-A Population Kinetic, Decision Analytic Approach.Journal of clinical medicine · 2019Article
- Serum β2-Microglobulin Is Closely Associated With the Recurrence Risk and 3-Month Outcome of Acute Ischemic Stroke.Frontiers in neurology · 2019Article
- Measurement and Estimation of Residual Kidney Function in Patients on Dialysis.Advances in chronic kidney disease · 2018Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Residual kidney function (RKF) contributes significant solute clearance in hemodialysis patients. Kidney Diseases Outcomes Quality Initiative (KDOQI) guidelines suggest that hemodialysis dose can be safely reduced in those with residual urea clearance (KRU) of 2 ml/min/1.73 m(2) or more. However, serial measurement of RKF is cumbersome and requires regular interdialytic urine collections. Simpler methods for assessing RKF are needed. β-trace protein (βTP) and β2-microglobulin (β2M) have been proposed as alternative markers of RKF. We derived predictive equations to estimate glomerular filtration rate (GFR) and KRU based on serum βTP and β2M from 191 hemodialysis patients based on standard measurements of KRU and GFR (mean of urea and creatinine clearances) using interdialytic urine collections. These modeled equations were tested in a separate validation cohort of 40 patients. A prediction equation for GFR that includes both βTP and β2M provided a better estimate than either alone and contained the terms 1/βTP, 1/β2M, 1/serum creatinine, and a factor for gender. The equation for KRU contained the terms 1/βTP, 1/β2M, and a factor for ethnicity. Mean bias between predicted and measured GFR was 0.63 ml/min and 0.50 ml/min for KRU. There was substantial agreement between predicted and measured KRU at a cut-off level of 2 ml/min/1.73 m(2). Thus, equations involving βTP and β2M provide reasonable estimates of RKF and could potentially be used to identify those with KRU of 2 ml/min/1.73 m(2) or more to follow the KDOQI incremental hemodialysis algorithm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.