ArticleKidney international2016
Estimating residual kidney function in dialysis patients without urine collection.
Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 81 citations in OpenAlex.
- Characterization of residual kidney function in chronic hemodialysis patients using plasma metabolomics.Scientific reports · 2026Article
- Expanded Hemodialysis with Theranova Dialyzer and Residual Kidney Function in Patients Starting Long-Term Hemodialysis: A Randomized Controlled Trial.Journal of the American Society of Nephrology : JASN · 2025Article
- Reference interval of free light chains ratio in patients with end-stage renal disease on chronic hemodialysis.Haematologica · 2024Article
- Twice Weekly versus Thrice Weekly Hemodialysis-A Pilot Cross-Over Equivalence Trial.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Residual Kidney Function in Hemodialysis: Its Importance and Contribution to Improved Patient Outcomes.Toxins · 2024Review
- Dialysis for older adults: why should the targets be different?Journal of nephrology · 2024Review
- Predicting solute transfer rate in patients initiating peritoneal dialysis.Journal of nephrology · 2024Article
- Choice of the Dialysis Modality: Practical Considerations.Journal of clinical medicine · 2023Review
- On the importance of the interplay of residual renal function with clinical outcomes in end-stage kidney disease.Journal of nephrology · 2022Review
- The combined clinical impact of red blood cell distribution width and vascular calcification on cardiovascular events and mortality in patients with endstage kidney disease.Kidney research and clinical practice · 2022Article
- Association between serum β2-microglobulin and mortality in Japanese peritoneal dialysis patients: A cohort study.PloS one · 2022Article
- Article
- Serum β2-microglobulin as a predictor of residual kidney function in peritoneal dialysis patients.Journal of nephrology · 2021Article
- Advanced glycation endproducts and dicarbonyls in end-stage renal disease: associations with uraemia and courses following renal replacement therapy.Clinical kidney journal · 2020Article
- Sex-specific relationship between vascular calcification and incident fracture in patients with end-stage renal disease.Kidney research and clinical practice · 2020Article
- Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?Jornal brasileiro de nefrologia · 2020Observational
- Narrative Review of Incremental Hemodialysis.Kidney international reports · 2020Review
- Renin Angiotensin Aldosterone System Blockades Does Not Protect Residual Renal Function in Patients with Hemodialysis at 1 Year After Dialysis Initiation: A Prospective Observational Cohort Study.Scientific reports · 2019Observational
- Predicting Residual Function in Hemodialysis and Hemodiafiltration-A Population Kinetic, Decision Analytic Approach.Journal of clinical medicine · 2019Article
- Factors associated with low trabecular bone scores in patients with end-stage kidney disease.Journal of bone and mineral metabolism · 2019Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Residual kidney function contributes substantially to solute clearance in dialysis patients but cannot be assessed without urine collection. We used serum filtration markers to develop dialysis-specific equations to estimate urinary urea clearance without the need for urine collection. In our development cohort, we measured 24-hour urine clearances under close supervision in 44 patients and validated these equations in 826 patients from the Netherlands Cooperative Study on the Adequacy of Dialysis. For the development and validation cohorts, median urinary urea clearance was 2.6 and 2.4 ml/min, respectively. During the 24-hour visit in the development cohort, serum β-trace protein concentrations remained in steady state but concentrations of all other markers increased. In the validation cohort, bias (median measured minus estimated clearance) was low for all equations. Precision was significantly better for β-trace protein and β2-microglobulin equations and the accuracy was significantly greater for β-trace protein, β2-microglobulin, and cystatin C equations, compared with the urea plus creatinine equation. Area under the receiver operator characteristic curve for detecting measured urinary urea clearance by equation-estimated urinary urea clearance (both 2 ml/min or more) were 0.821, 0.850, and 0.796 for β-trace protein, β2-microglobulin, and cystatin C equations, respectively; significantly greater than the 0.663 for the urea plus creatinine equation. Thus, residual renal function can be estimated in dialysis patients without urine collections.
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