ArticleKidney international2016
A label-free approach by infrared spectroscopic imaging for interrogating the biochemistry of diabetic nephropathy progression.
Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 47 citations in OpenAlex.
- Developing a Label-Free Infrared Spectroscopic Analysis with Chemometrics and Computational Enhancement for Assessing Lupus Nephritis Activity.Biosensors · 2025Article
- Fructosyl Amino Oxidase as a Therapeutic Enzyme in Age-Related Macular Degeneration.International journal of molecular sciences · 2024Article
- Non-Perturbative Identification and Subtyping of Amyloidosis in Human Kidney Tissue with Raman Spectroscopy and Machine Learning.Biosensors · 2023Article
- The Potential Use of Near- and Mid-Infrared Spectroscopy in Kidney Diseases.International journal of molecular sciences · 2023Review
- FTIR Analysis of Renal Tissue for the Assessment of Hypertensive Organ Damage and proANPInternational journal of molecular sciences · 2023Article
- Urinalysis of individuals with renal hyperfiltration using ATR-FTIR spectroscopy.Scientific reports · 2022Article
- Automated Computational Detection of Disease Activity in ANCA-Associated Glomerulonephritis Using Raman Spectroscopy: A Pilot Study.Molecules (Basel, Switzerland) · 2022Article
- Statistical Considerations and Tools to Improve Histopathologic Protocols with Spectroscopic Imaging.Applied spectroscopy · 2022Article
- Simultaneous Characterization of Implant Wear and Tribocorrosion Debris within Its Corresponding Tissue Response Using Infrared Chemical Imaging.Biotribology (Oxford) · 2021Article
- Distinguishing active from quiescent disease in ANCA-associated vasculitis using attenuated total reflection Fourier-transform infrared spectroscopy.Scientific reports · 2021Article
- Artificial intelligence and algorithmic computational pathology: an introduction with renal allograft examples.Histopathology · 2021Review
- Fourier Transform Infrared Spectroscopy: An Innovative Method for the Diagnosis of Ovarian Cancer.Cancer management and research · 2021Review
- Synergy Effect of Combined Near and Mid-Infrared Fibre Spectroscopy for Diagnostics of Abdominal Cancer.Sensors (Basel, Switzerland) · 2020Article
- Fructosamine-3-Kinase as a Potential Treatment Option for Age-Related Macular Degeneration.Journal of clinical medicine · 2020Article
- Banff Digital Pathology Working Group: Going digital in transplant pathology.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Infrared spectral microscopy as a tool to monitor lung fibrosis development in a model system.Biomedical optics express · 2020Article
- A New Artificial Urine Protocol to Better Imitate Human Urine.Scientific reports · 2019Article
- Detection and Characterization of a Biochemical Signature Associated with Diabetic Nephropathy Using Near-infrared Spectroscopy on Tissue Sections.Journal of clinical medicine · 2019Article
- Standardization of complex biologically derived spectrochemical datasets.Nature protocols · 2019Article
- Integration of diffraction phase microscopy and Raman imaging for label-free morpho-molecular assessment of live cells.Journal of biophotonics · 2019Article
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5 authors at 1 institution in 1 country.
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Abstract
Routine histology, the current gold standard, involves staining for specific biomolecules. However, untapped biochemical information in tissue can be gathered using biochemical imaging. Infrared spectroscopy is an emerging modality that allows label-free chemical imaging to derive biochemical information (such as protein, lipids, DNA, collagen) from tissues. Here we employed this technology in order to better predict the development of diabetic nephropathy. Using human primary kidney biopsies or nephrectomies, we obtained tissue from 4 histologically normal kidneys, 4 histologically normal kidneys from diabetic subjects, and 5 kidneys with evidence of diabetic nephropathy. A biochemical signature of diabetic nephropathy was derived that enabled prediction of nephropathy based on the ratio of only 2 spectral frequencies. Nonetheless, using the entire spectrum of biochemical information, we were able to detect renal disease with near-perfect accuracy. Additionally, study of sequential protocol biopsies from 3 transplanted kidneys showed biochemical changes even prior to clinical manifestation of diabetic nephropathy. Thus, infrared imaging can identify critical biochemical alterations that precede morphologic changes, potentially allowing for earlier intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.