ArticleThe European journal of neuroscience2016
Dorsolateral neostriatum contribution to incentive salience: opioid or dopamine stimulation makes one reward cue more motivationally attractive than another.
Article in The European journal of neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 72 citations in OpenAlex.
- 20 Years of Aberrant Salience in Psychosis: What Have We Learned?The American journal of psychiatry · 2025Review
- The Incentive-Sensitization Theory of Addiction 30 Years On.Annual review of psychology · 2025Review
- Mesocorticolimbic system reactivity to alcohol use-related visual cues as a function of alcohol sensitivity phenotype: A pilot fMRI study.Addiction neuroscience · 2024Article
- The Role of Estrogen Signaling and Exercise in Drug Abuse: A Review.Clinics and practice · 2024Article
- Ventromedial frontoinsular connectivity is associated with long-term smoking behavior change in aging.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Separating desire from prediction of outcome value.Trends in cognitive sciences · 2023Review
- Dopamine-mediated striatal activity and function is enhanced in GlyRα2 knockout animals.iScience · 2023Article
- Reinstatement of Pavlovian responses to alcohol cues by stress.Psychopharmacology · 2023Article
- Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues.Nature communications · 2022Article
- Article
- Quantifying the instrumental and noninstrumental underpinnings of Pavlovian responding with the Price equation.Psychonomic bulletin & review · 2022Review
- μ-opioid receptor availability is associated with sex drive in human males.Cognitive, affective & behavioral neuroscience · 2022Article
- The incentive amplifying effects of nicotine: Roles in alcohol seeking and consumption.Advances in pharmacology (San Diego, Calif.) · 2022Review
- Incentive motivation: 'wanting' roles of central amygdala circuitry.Behavioural brain research · 2021Review
- Dopaminergic Control of the Feeding Circuit.Endocrinology and metabolism (Seoul, Korea) · 2021Review
- A proposed role for glucocorticoids in mediating dopamine-dependent cue-reward learning.Stress (Amsterdam, Netherlands) · 2021Article
- Nicotine Enhances Goal-Tracking in Ethanol and Food Pavlovian Conditioned Approach Paradigms.Frontiers in neuroscience · 2021Article
- Thirst recruits phasic dopamine signaling through subfornical organ neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- 'Liking' and 'wanting' in eating and food reward: Brain mechanisms and clinical implications.Physiology & behavior · 2020Review
- Effects of the cannabinoid receptor agonist CP-55,940 on incentive salience attribution.Psychopharmacology · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Pavlovian cues for rewards can become attractive incentives: approached and 'wanted' as the rewards themselves. The motivational attractiveness of a previously learned cue is not fixed, but can be dynamically amplified during re-encounter by simultaneous activation of brain limbic circuitry. Here it was reported that opioid or dopamine microinjections in the dorsolateral quadrant of the neostriatum (DLS) of rats selectively amplify attraction toward a previously learned Pavlovian cue in an individualized fashion, at the expense of a competing cue. In an autoshaping (sign-tracking vs. goal-tracking) paradigm, microinjection of the mu opioid receptor agonist (DAMGO) or dopamine indirect agonist (amphetamine) in the DLS of sign-tracker individuals selectively enhanced their sign-tracking attraction toward the reward-predictive lever cue. By contrast, DAMGO or amphetamine in the DLS of goal-trackers selectively enhanced prepotent attraction toward the reward-proximal cue of sucrose dish. Amphetamine also enhanced goal-tracking in some sign-tracker individuals (if they ever defected to the dish even once). That DLS enhancement of cue attraction was due to stronger motivation, not stronger habits, was suggested by: (i) sign-trackers flexibly followed their cue to a new location when the lever was suddenly moved after DLS DAMGO microinjection; and (ii) DAMGO in the DLS also made sign-trackers work harder on a new instrumental nose-poke response required to earn presentations of their Pavlovian lever cue (instrumental conditioned reinforcement). Altogether, the current results suggest that DLS circuitry can enhance the incentive salience of a Pavlovian reward cue, selectively making that cue a stronger motivational magnet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.