ArticleScientific reports2016
Intraoperative Identification of Liver Cancer Microfoci Using a Targeted Near-Infrared Fluorescent Probe for Imaging-Guided Surgery.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 69 citations in OpenAlex.
- Innovative applications of silicon dioxide nanoparticles for targeted liver cancer treatment.Frontiers in bioengineering and biotechnology · 2025Review
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- Proteinoid Polymers and Nanocapsules for Cancer Diagnostics, Therapy and Theranostics: In Vitro and In Vivo Studies.Journal of functional biomaterials · 2023Review
- Near-infrared fluorescence imaging of hepatocellular carcinoma cells regulated by β-catenin signaling pathway.Frontiers in oncology · 2023Article
- Multiplexed imaging in oncology.Nature biomedical engineering · 2022Review
- Emerging indocyanine green-integrated nanocarriers for multimodal cancer therapy: a review.Nanoscale advances · 2021Review
- Recent Progress of Near-Infrared Fluorescence in vivo Bioimaging in the Second and Third Biological Window.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
- A two-in-one Janus NIR-II AIEgen with balanced absorption and emission for image-guided precision surgery.Materials today. Bio · 2021Article
- Synthesis of fluorescent nanoprobe with simultaneous response to intracellular pH and ZnMikrochimica acta · 2021Article
- Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection.Frontiers in bioengineering and biotechnology · 2021Article
- A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma.Annals of translational medicine · 2021Review
- Article
- Image-guided tumor surgery: The emerging role of nanotechnology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- Emerging and Innovative Theranostic Approaches for Mesoporous Silica Nanoparticles in Hepatocellular Carcinoma: Current Status and Advances.Frontiers in bioengineering and biotechnology · 2020Review
- Theragnostic potentials of core/shell mesoporous silica nanostructures.Nanotheranostics · 2019Review
- NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer.Nature communications · 2018Article
- Differentiation-inducing therapeutic effect of Notch inhibition in reversing malignant transformation of liver normal stem cells via MET.Oncotarget · 2018Article
- Indocyanine green-incorporating nanoparticles for cancer theranostics.Theranostics · 2018Review
- Innovative treatment for hepatocellular carcinoma (HCC).Translational gastroenterology and hepatology · 2018Review
- New horizons in multimodality molecular imaging and novel radiotracers.Clinical medicine (London, England) · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Difficulties in the highly sensitive detection of tumour microfoci represent a critical obstacle toward improved surgical intervention in liver cancer. Conventional preoperative imaging methods and surgeons' subjective experience are limited by their inability to effectively detect tumour lesions measuring less than 2 mm; however, intraoperative fluorescence molecular imaging may overcome this limitation. Here, we synthesised an arginine-glycine-aspartic acid (RGD)-conjugated mesoporous silica nanoparticle (MSN) highly loaded with indocyanine green (ICG) dye that could accurately delineate liver cancer margins and provide excellent tumour-to-normal tissue contrast intraoperatively. The increased ICG loading capacity and tumour specificity enabled the identification of residual microtumours and satellite lesions measuring less than 1 mm in living mice. Histological analysis validated the sensitivity and accuracy of this approach. We believe this technique utilising a new fluorescent nanoprobe with intraoperative optical imaging may offer a more sensitive and accurate method for liver cancer resection guidance, resulting in better surgical outcomes.
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