ArticleStem cell reports2016
BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo.
Article in Stem cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Experimental study on the effect of warm acupuncture on the healing of bone nonunion in rats.Journal of the Chinese Medical Association : JCMA · 2026Article
- Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture.Stem cell reports · 2024Article
- Cellular crosstalk in the bone marrow niche.Journal of translational medicine · 2024Review
- The molecular and cellular hematopoietic stem cell specification niche.Experimental hematology · 2024Review
- Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo.Nature communications · 2024Article
- Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity.Cell reports · 2022Article
- Using Pluripotent Stem Cells to Understand Normal and Leukemic Hematopoietic Development.Stem cells translational medicine · 2022Review
- Glioma stem cells and neural stem cells respond differently to BMP4 signaling.Cell regeneration (London, England) · 2022Article
- p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion.Blood · 2022Article
- PDGFRβCell reports · 2022Article
- Bone Marrow Niches of Hematopoietic Stem and Progenitor Cells.International journal of molecular sciences · 2022Review
- Review
- The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.Cell reports · 2021Article
- BMP signaling is required for postnatal murine hematopoietic stem cell self-renewal.Haematologica · 2021Article
- Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies.Frontiers in immunology · 2021Review
- Review
- Training the Fetal Immune System Through Maternal Inflammation-A Layered Hygiene Hypothesis.Frontiers in immunology · 2020Review
- Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.The Journal of experimental medicine · 2019Article
- CD157 and CD200 at the crossroads of endothelial remodeling and immune regulation.Stem cell investigation · 2019Article
- Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish.Blood advances · 2018Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
Hematopoietic stem cells (HSC), the self-renewing cells of the adult blood differentiation hierarchy, are generated during embryonic stages. The first HSCs are produced in the aorta-gonad-mesonephros (AGM) region of the embryo through endothelial to a hematopoietic transition. BMP4 and Hedgehog affect their production and expansion, but it is unknown whether they act to affect the same HSCs. In this study using the BRE GFP reporter mouse strain that identifies BMP/Smad-activated cells, we find that the AGM harbors two types of adult-repopulating HSCs upon explant culture: One type is BMP-activated and the other is a non-BMP-activated HSC type that is indirectly controlled by Hedgehog signaling through the VEGF pathway. Transcriptomic analyses demonstrate that the two HSC types express distinct but overlapping genetic programs. These results revealing the bifurcation in HSC types at early embryonic stages in the AGM explant model suggest that their development is dependent upon the signaling molecules in the microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.