Evidence map›Paper›PMID 26923698›Full record

ArticleBioorganic & medicinal chemistry letters2016

Poly-arginine conjugated triarylmethyl radical as intracellular spin label.

Benoit Driesschaert, Andrey A Bobko, Timothy D Eubank, Alexandre Samouilov, Valery V Khramtsov, Jay L Zweier

Open access · greenAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Benoit DriesschaertIn Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, WV 26506, United States; Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, United States.
Andrey A BobkoIn Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, WV 26506, United States; Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, United States.
Timothy D EubankIn Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, WV 26506, United States; Department of Microbiology, Immunology & Cell Biology, West Virginia University School of Medicine, Morgantown, WV 26506, United States.
Alexandre SamouilovDavis Heart & Lung Research Institute, The Ohio State University/Wexner Medical Center, 460 West 12th Avenue, BRT 0390, Columbus, OH 43210, United States.
Valery V KhramtsovIn Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, WV 26506, United States; Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, United States.
Jay L ZweierDavis Heart & Lung Research Institute, The Ohio State University/Wexner Medical Center, 460 West 12th Avenue, BRT 0390, Columbus, OH 43210, United States. Electronic address: jay.zweier@osumc.edu.
West Virginia University · USThe Ohio State University Wexner Medical Center · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
In vivo monitoring of tumor microenvironment regulation for macrophagesR01CA194013 · NCI · WEST VIRGINIA UNIVERSITY · PI Timothy D Eubank, Valery V Khramtsov · 2015 to 2026
$3.5M
Profiling chemical tumor microenvironment: Application for diagnostics & therapyR01CA192064 · NCI · WEST VIRGINIA UNIVERSITY · PI EUBANK, TIMOTHY D, KHRAMTSOV, VALERY V · 2015 to 2024
$3.4M
Integration of High Field MRI and EPRI For Functional ImagingR01EB016096 · NIBIB · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2013 to 2016
$2.3M
Functional proton-electron double-resonance imaging: development and applicationR01EB014542 · NIBIB · OHIO STATE UNIVERSITY · PI KHRAMTSOV, VALERY V, SAMOUILOV, ALEXANDRE VALENTIN · 2012 to 2015
$1.3M
NCI NIH HHS CA192064NCI NIH HHS CA194013NCI NIH HHS R01 CA192064NCI NIH HHS R01 CA194013NIBIB NIH HHS EB014542NIBIB NIH HHS EB016096NIBIB NIH HHS R01 EB014542NIBIB NIH HHS R01 EB016096NIGMS NIH HHS U54 GM104942NIGMS NIH HHS U54GM104942
6 · The paper itself

Abstract

Stable triarylmethyl radicals are ideal spin labels used for biomedical electron paramagnetic resonance applications. Previously reported structures exhibit polar charged functions for water solubilization preventing them from crossing the cell membrane. We report the synthesis of a triarylmethyl radical conjugated to poly-arginine peptide allowing intracellular delivery of the paramagnetic label.

Indexed as

Electron Spin Resonance SpectroscopyCell Line, TumorHumansMethanePeptidesSpin LabelsMethanemethyl radicalPeptidespolyarginineSpin LabelsCyclic voltammetryEPRPoly-arginineRadicalTAM

Identifiers

PMID26923698
PMCPMC4807691
OpenAlexW2286997823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.