Evidence map›Paper›PMID 26923645›Full record

ArticleVisual neuroscience2016

Noninvasive imaging of the thirteen-lined ground squirrel photoreceptor mosaic.

Benjamin Sajdak, Yusufu N Sulai, Christopher S Langlo, Gabriel Luna, Steven K Fisher, Dana K Merriman, Alfredo Dubra

Open access · hybridAbstract read
In one paragraph

Article in Visual neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 33 citations in OpenAlex.

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  11. Characterization of Retinal Development in 13-Lined Ground Squirrels.Translational vision science & technology · 2022
    Article
  12. Article
  13. Impact of Photoreceptor Loss on Retinal Circuitry.Annual review of vision science · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Noninvasive Imaging of Cone Ablation and Regeneration in Zebrafish.Translational vision science & technology · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Benjamin SajdakDepartment of Cell Biology, Neurobiology, & Anatomy,Medical College of Wisconsin,Milwaukee,Wisconsin.
Yusufu N SulaiDepartment of Ophthalmology,Medical College of Wisconsin,Milwaukee,Wisconsin.
Christopher S LangloDepartment of Cell Biology, Neurobiology, & Anatomy,Medical College of Wisconsin,Milwaukee,Wisconsin.
Gabriel LunaNeuroscience Research Institute,University of California, Santa Barbara,Santa Barbara,California.
Steven K FisherNeuroscience Research Institute,University of California, Santa Barbara,Santa Barbara,California.
Dana K MerrimanDepartment of Biology,University of Wisconsin Oshkosh,Oshkosh,Wisconsin.
Alfredo DubraDepartment of Cell Biology, Neurobiology, & Anatomy,Medical College of Wisconsin,Milwaukee,Wisconsin.
Medical College of Wisconsin · USUniversity of California, Santa Barbara · USUniversity of Wisconsin–Oshkosh · US

Funding

MORPHOLOGY MODULEP30EY001931 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI BURKE, JANICE M. · 1985 to 2016
$9.8M
Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Platform Technologies for Microscopic Retinal Imaging: Development & TranslationU01EY025477 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2015 to 2019
$4.4M
Rresearch Training Program in Vision ScienceT32EY014537 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Elena V Semina · 2002 to 2026
$4.2M
VISION RES LAB: HERPETIC KERATIC, CORE PIGMENT GENES, RETINITIS PIGMENTOSAC06RR016511 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI DUNN, MICHAEL J · 2002 to 2002
$1.4M
NCRR NIH HHS C06 RR016511NCRR NIH HHS C06RR016511NEI NIH HHS P30 EY001931NEI NIH HHS P30EY001931NEI NIH HHS T32 EY014537NEI NIH HHS T32EY014537NEI NIH HHS U01 EY025477NEI NIH HHS U01EY025477NIGMS NIH HHS T32 GM080202NIGMS NIH HHS T32GM080202
6 · The paper itself

Abstract

Ground squirrels are an increasingly important model for studying visual processing, retinal circuitry, and cone photoreceptor function. Here, we demonstrate that the photoreceptor mosaic can be longitudinally imaged noninvasively in the 13-lined ground squirrel (Ictidomys tridecemlineatus) using confocal and nonconfocal split-detection adaptive optics scanning ophthalmoscopy using 790 nm light. Photoreceptor density, spacing, and Voronoi analysis are consistent with that of the human cone mosaic. The high imaging success rate and consistent image quality in this study reinforce the ground squirrel as a practical model to aid drug discovery and testing through longitudinal imaging on the cellular scale.

Indexed as

AnimalsFemaleMaleOphthalmoscopyRetinal Cone Photoreceptor CellsRetinal Rod Photoreceptor CellsSciuridaeAdaptive opticsPhotoreceptorsRetinal imagingRodentVisual streak

Identifiers

PMID26923645
PMCPMC4793898
OpenAlexW2265056331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.