ArticleCurrent treatment options in neurology2016
Nutraceuticals in Acute and Prophylactic Treatment of Migraine.
Article in Current treatment options in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Global hotspots and trends of nutritional supplements for sick populations from 2000 to 2024.Frontiers in nutrition · 2025Pooled it
- Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis.BMJ open · 2021Pooled it
- Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial.The journal of headache and pain · 2021Trial
- The Brain, the Eating Plate, and the Gut Microbiome: Partners in Migraine Pathogenesis.Nutrients · 2024Review
- All Roads Lead to the Gut: The Importance of the Microbiota and Diet in Migraine.Neurology international · 2023Review
- Magnesium as an Important Factor in the Pathogenesis and Treatment of Migraine-From Theory to Practice.Nutrients · 2022Review
- Petasites for Migraine Prevention: New Data on Mode of Action, Pharmacology and Safety. A Narrative Review.Frontiers in neurology · 2022Review
- Applications of Ketogenic Diets in Patients with Headache: Clinical Recommendations.Nutrients · 2021Review
- The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?Cureus · 2021Review
- Herbal Medicine for Pain Management: Efficacy and Drug Interactions.Pharmaceutics · 2021Review
- Non-Pharmacological Approaches to Headaches: Non-Invasive Neuromodulation, Nutraceuticals, and Behavioral Approaches.International journal of environmental research and public health · 2021Review
- Dietary Intake of Calcium and Magnesium in Relation to Severe Headache or Migraine.Frontiers in nutrition · 2021Article
- Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis.Journal of clinical medicine · 2020Article
- Advances in paediatrics in 2019: current practices and challenges in allergy, endocrinology, gastroenterology, public health, neonatology, nutrition, nephrology, neurology, respiratory diseases and rheumatic diseases.Italian journal of pediatrics · 2020Review
- The Use of Antioxidants in the Treatment of Migraine.Antioxidants (Basel, Switzerland) · 2020Review
- Mitochondria in migraine pathophysiology - does epigenetics play a role?Archives of medical science : AMS · 2019Article
- An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache.Italian journal of pediatrics · 2019Observational
- The Effect of Magnesium Deficiency on Neurological Disorders: A Narrative Review Article.Iranian journal of public health · 2019Review
- A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study.BMC complementary and alternative medicine · 2017Observational
- The use of nutraceutics in children's and adolescent's headache.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
opinion statementPeople who suffer from headaches often prefer nutraceutical treatment over traditional pharmacological approaches, due to fear of possible side effects, drug dependence, or addiction. Since treatment with nutraceuticals does not require a doctor's prescription, many patients rely on their own judgment as to when and which one to take, often without consultation or guidance from their physician. Some physicians could provide information about potential efficacy and side effects of various products, but many are not familiar with the nutraceuticals. Widespread skepticism persists among doctors about the effectiveness of these treatments. This is largely due to the lack of rigorous clinical studies. However, even when incontrovertible scientific evidence exists, many physicians remain distrustful of the evidence. The following review summarizes randomized controlled trials of some of the most commonly used non-pharmacological treatments, including magnesium, coenzyme Q10, riboflavin (vitamin B2), petasites, and feverfew (Table 1).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.