ArticleCell reports2016
Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer.
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Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers.
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211citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
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211 citing papers in PubMed, 313 citations in OpenAlex.
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- Population-Associated Molecular Variation in Histologically Normal Breast Tissue Is Associated with Distinct Baseline Transcriptional States.International journal of molecular sciences · 2026Article
- Age-Associated NAD+ Decline and Mitochondrial Dysfunction Predispose Cells to a Reversible Tumor-Permissive Metabolic State.Biology · 2026Article
- Opposing roles of DGAT-mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity.The FEBS journal · 2026Article
- Fatty acid metabolism in glioma: a review of novel targets and therapeutic strategies.Chinese neurosurgical journal · 2026Review
- Preferential enhancement of mitochondria-mediated apoptosis and modulation of metastasis-related markers by etoposide-loaded nanoparticles in breast cancer cell lines.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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- CPT1A drives cisplatin resistance via acetylation‑dependent activation of DRP1 and mitochondrial fission in small cell lung cancer.Cell death & disease · 2026Article
- Metabolic Vulnerabilities as a Therapeutic Target in Breast Cancer.Current oncology (Toronto, Ont.) · 2026Review
- Pioglitazone Mitigates Arsenic-Induced Cardiotoxicity via Lipid Metabolism: Network Pharmacology and Molecular Docking Approach.Cardiovascular toxicology · 2026Article
- Mitochondria-nucleus communication dictates progressive versus bimodal aging of the mammary gland.bioRxiv : the preprint server for biology · 2026Article
- Ophiobolin A impacts mitochondrial redox biology in an epithelial-mesenchymal transition (EMT)-specific manner.Cancer cell international · 2026Article
- DRESIS 2.0: the comprehensive landscape of drug resistance information.Nucleic acids research · 2026Article
- Pharmacological Myristoylation Inhibition by Zelenirstat Disrupts Growth Signalling, Energy Metabolism, and Migration in Triple-Negative Breast Cancer Cells.Breast cancer (Dove Medical Press) · 2026Article
- Dynamic Metabolic States in TNBC: Orchestrating Spatiotemporal Adaptation and Therapy.Oncology research · 2026Review
- Lipid Metabolic Reprogramming in Breast Cancer: Mechanisms and Emerging Therapeutic Strategies.Breast cancer (Dove Medical Press) · 2026Review
- Mortality differences in coronary patients with breast cancer treated with trimetazidine dihydrochloride: potential therapeutic implications.Cardio-oncology (London, England) · 2025Article
- Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapy.Annals of medicine · 2025Review
151 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 6 institutions in 2 countries.
Jun Hyoung ParkDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Sajna VithayathilDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Santosh KumarDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Pi-Lin SungDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Institute of Clinical Medicine, National Yang-Ming University and Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Lacey Elizabeth DobroleckiLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Vasanta PutluriDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Vadiraja B BhatAgilent Technologies, Wilmington, DE 19808, USA.
Salil Kumar BhowmikDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Vineet GuptaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Kavisha AroraDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Danli WuCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Efrosini TsoukoCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Yiqun ZhangDan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Suman MaityDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Taraka R DontiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Brett H GrahamDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Daniel E FrigoCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA; Genomic Medicine Program, Houston Methodist Research Institute, Houston, TX 77030, USA.
Cristian CoarfaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Patricia YotndaCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Nagireddy PutluriDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Arun SreekumarDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Michael T LewisLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Chad J CreightonDan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Lee-Jun C WongDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: ljwong@bcm.edu.
Benny Abraham KaipparettuDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: kaippare@bcm.edu.
Baylor College of Medicine · USChildren's Cancer Center · USAgilent Technologies (United States) · USHouston Methodist · USNational Yang Ming Chiao Tung University · TWUniversity of Houston · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MVirology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7MTRANSFORMING GROWTH FACTOR ALPHA IN PATHOGENESIS OF BREAST CANCERP01CA030195 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI OESTERREICH, STEFFI · 1985 to 2009
$16.8MThe Core of the Computational BiologyU54CA149196 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WONG, STEPHEN TC · 2010 to 2015
$10.6MGenetic & Metabolic Dissection of the CaMKKbeta Signaling Axis in Prostate CancerR01CA184208 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FRIGO, DANIEL EDWARD · 2015 to 2019
$1.9MDelineating racially distinct metabolic pathways in triple negative breast cancerU01CA179674 · NCI · BAYLOR COLLEGE OF MEDICINE · PI SREEKUMAR, ARUN · 2014 to 2018
$1.7MBreast cancer response markers to a dual HER1/2 blockerR01CA112305 · NCI · BAYLOR COLLEGE OF MEDICINE · PI CHANG, JENNY C-N · 2005 to 2009
$1.3MMitochondria-nuclear crosstalk in triple negative breast cancer racial disparityR21CA179720 · NCI · BAYLOR COLLEGE OF MEDICINE · PI KAIPPARETTU, BENNY ABRAHAM · 2013 to 2015
$623kBD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430kHigh Kynurenine in Agressive Triple Negative African American Breast CancerR21CA185516 · NCI · BAYLOR COLLEGE OF MEDICINE · PI SREEKUMAR, ARUN · 2014 to 2015
$374kMitochondria specific metabolomic signature in triple negative breast cancer metaR21CA173150 · NCI · BAYLOR COLLEGE OF MEDICINE · PI KAIPPARETTU, BENNY ABRAHAM · 2013 to 2014
$369kMECHANISM OF ANTICARCINOGENIC ACTION OF TIMPR01CA050183 · NCI · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI DENHARDT, DAVID T · 1990 to 1994
–NCI NIH HHS NIH-R01CA184208NCI NIH HHS P01 CA030195NCI NIH HHS P01CA30195NCI NIH HHS P30 CA125123NCI NIH HHS P50CA50183NCI NIH HHS R01 CA112305NCI NIH HHS R01CA112305NCI NIH HHS R01 CA184208NCI NIH HHS R21 CA173150NCI NIH HHS R21CA173150NCI NIH HHS R21 CA179720NCI NIH HHS R21CA179720NCI NIH HHS R21CA179720S1NCI NIH HHS R21CA179720S2NCI NIH HHS R21 CA185516NCI NIH HHS R21CA185516NCI NIH HHS U01 CA179674NCI NIH HHS U01CA179674NCI NIH HHS U54 CA149196NCI NIH HHS U54-CA149196NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211PHS HHS NCRR S10RR024574PHS HHS NIAID P30AI036211
Abstract
Transmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondrial reprogramming and mitochondria-regulated cancer pathways in triple-negative breast cancer (TNBC). Analysis of cybrids and established breast cancer (BC) cell lines showed that metastatic TNBC maintains high levels of ATP through fatty acid β oxidation (FAO) and activates Src oncoprotein through autophosphorylation at Y419. Manipulation of FAO including the knocking down of carnitine palmitoyltransferase-1A (CPT1) and 2 (CPT2), the rate-limiting proteins of FAO, and analysis of patient-derived xenograft models confirmed the role of mitochondrial FAO in Src activation and metastasis. Analysis of TCGA and other independent BC clinical data further reaffirmed the role of mitochondrial FAO and CPT genes in Src regulation and their significance in BC metastasis.
Indexed as
Energy MetabolismAnimalsCarcinogenesisCell Line, TumorFatty AcidsFemaleHumansMice, SCIDMitochondriaNeoplasm TransplantationOxidation-ReductionPhosphorylationProtein Processing, Post-Translationalsrc-Family KinasesTriple Negative Breast NeoplasmsFatty Acidssrc-Family Kinases
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