ArticleBiomaterials2016
Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo.
Article in Biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 113 citations in OpenAlex.
- Dexamethasone in preventive analgesia alleviates pain and complications after jaw cyst enucleation: a randomized controlled trial.BMC anesthesiology · 2022Trial
- Chronic alteration of CaBiomaterials · 2026Article
- Convection-enhanced delivery of dexamethasone in glioma models suppresses myeloid inflammation while avoiding systemic toxicities.The Journal of clinical investigation · 2026Article
- Microglia surveillance is directed toward neuron activation during sustained intracortical microstimulation.Journal of neural engineering · 2026Article
- Multifunctional nanoplatforms for optic nerve regeneration integrating anti-inflammatory, epigenetic, and ionic mechanisms with emerging artificial intelligence technologies.Cell biology and toxicology · 2025Review
- Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates.Journal of neural engineering · 2025Article
- Chronic alteration of CabioRxiv : the preprint server for biology · 2025Article
- Dexamethasone-loaded platelet-inspired nanoparticles improve intracortical microelectrode recording performance.Nature communications · 2025Article
- Detection of Neuronal Glutamate in Brain Extracellular Space In Vivo Using Microdialysis and Metabolic Labeling with Glutamine.ACS chemical neuroscience · 2025Article
- Revolutionizing brain‒computer interfaces: overcoming biocompatibility challenges in implantable neural interfaces.Journal of nanobiotechnology · 2025Review
- Systemically administered platelet-inspired nanoparticles to reduce inflammation surrounding intracortical microelectrodes.Biomaterials · 2025Article
- Long-Term Neural Recording Performance of PEDOT/CNT/Dexamethasone Coated Electrode Array Implanted in Visual Cortex of Rats.Advanced nanobiomed research · 2025Article
- Lipopolysaccharide Effects on Neurotransmission: Understanding Implications for Depression.ACS chemical neuroscience · 2024Review
- Enhancing biocompatibility of the brain-machine interface: A review.Bioactive materials · 2024Review
- Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation.Nature communications · 2024Article
- Dopamine Concentration Changes Associated with the Retrodialysis of Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) into the Caudate Putamen.Brain sciences · 2024Article
- Reactive Amine Functionalized Microelectrode Arrays Provide Short-Term Benefit but Long-Term Detriment toACS applied bio materials · 2024Article
- Cell-specific alterations in autophagy-lysosomal activity near the chronically implanted microelectrodes.Biomaterials · 2023Article
- Pro-myelinating clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health.Biomaterials · 2023Article
- Dexamethasone-Enhanced Continuous Online Microdialysis for Neuromonitoring of OACS chemical neuroscience · 2023Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Intracortical neural probes enable researchers to measure electrical and chemical signals in the brain. However, penetration injury from probe insertion into living brain tissue leads to an inflammatory tissue response. In turn, microglia are activated, which leads to encapsulation of the probe and release of pro-inflammatory cytokines. This inflammatory tissue response alters the electrical and chemical microenvironment surrounding the implanted probe, which may in turn interfere with signal acquisition. Dexamethasone (Dex), a potent anti-inflammatory steroid, can be used to prevent and diminish tissue disruptions caused by probe implantation. Herein, we report retrodialysis administration of dexamethasone while using in vivo two-photon microscopy to observe real-time microglial reaction to the implanted probe. Microdialysis probes under artificial cerebrospinal fluid (aCSF) perfusion with or without Dex were implanted into the cortex of transgenic mice that express GFP in microglia under the CX3CR1 promoter and imaged for 6 h. Acute morphological changes in microglia were evident around the microdialysis probe. The radius of microglia activation was 177.1 μm with aCSF control compared to 93.0 μm with Dex perfusion. T-stage morphology and microglia directionality indices were also used to quantify the microglial response to implanted probes as a function of distance. Dexamethasone had a profound effect on the microglia morphology and reduced the acute activation of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.