Evidence map›Paper›PMID 26923186›Full record

ArticleBiochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology2016

Physical models have gender-specific effects on student understanding of protein structure-function relationships.

Robin M Forbes-Lorman, Michelle A Harris, Wesley S Chang, Erik W Dent, Erik V Nordheim, Margaret A Franzen

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
14.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Biochemistry Learning in Higher Education: A Systematic Review on Methodologies and Teaching Resources.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
    Pooled it
  2. Article
  3. Teaching meiosis with the DNA triangle framework: A classroom activity that changes how students think about chromosomes.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2022
    Article
  4. Article
  5. Physical models can provide superior learning opportunities beyond the benefits of active engagements.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2018
    Article
  6. 3D-Printed Protein Models as an Educational Tool in Biochemistry Outreach.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robin M Forbes-LormanBiology Core Curriculum, University of Wisconsin-Madison, Madison, Wisconsin.
Michelle A HarrisBiology Core Curriculum, University of Wisconsin-Madison, Madison, Wisconsin.
Wesley S ChangDepartment of Statistics, University of Wisconsin-Madison, Madison, Wisconsin.
Erik W DentDepartment of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin.
Erik V NordheimDepartment of Statistics, University of Wisconsin-Madison, Madison, Wisconsin.
Margaret A FranzenCenter for Biomolecular Modeling, Milwaukee School of Engineering, Milwaukee, Wisconsin.
University of Wisconsin–Madison · USMilwaukee School of Engineering · US

Funding

Role of F-BAR proteins in neuronal developmentR01NS080928 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DENT, ERIK W · 2013 to 2017
$1.6M
NINDS NIH HHS R01 NS080928
6 · The paper itself

Abstract

Understanding how basic structural units influence function is identified as a foundational/core concept for undergraduate biological and biochemical literacy. It is essential for students to understand this concept at all size scales, but it is often more difficult for students to understand structure-function relationships at the molecular level, which they cannot as effectively visualize. Students need to develop accurate, 3-dimensional mental models of biomolecules to understand how biomolecular structure affects cellular functions at the molecular level, yet most traditional curricular tools such as textbooks include only 2-dimensional representations. We used a controlled, backward design approach to investigate how hand-held physical molecular model use affected students' ability to logically predict structure-function relationships. Brief (one class period) physical model use increased quiz score for females, whereas there was no significant increase in score for males using physical models. Females also self-reported higher learning gains in their understanding of context-specific protein function. Gender differences in spatial visualization may explain the gender-specific benefits of physical model use observed. © 2016 The Authors Biochemistry and Molecular Biology Education published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 44(4):326-335, 2016.

Indexed as

ComprehensionLearningModels, AnatomicRecognition, PsychologyBiochemistryComputer GraphicsFemaleHumansImaging, Three-DimensionalMaleMicrotubule-Associated ProteinsMinor Histocompatibility AntigensProtein Structure, SecondaryStructure-Activity RelationshipStudentsMicrotubule-Associated ProteinsMinor Histocompatibility AntigensTRIP10 protein, humanassessmentexternal representationsgender differencesphysical modelsprotein structure-function

Identifiers

PMID26923186
PMCPMC4936926
OpenAlexW2290570892

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.