ReviewBrain research2016
Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.
Open access · hybridAbstract readReview
In one paragraph
Review in Brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
- Targeting EDEM protects against ER stress and improves development and survival in C. elegans.PLoS genetics · 2022Article
- Unique three-site compound heterozygous mutation in the WFS1 gene in Wolfram syndrome.BMC endocrine disorders · 2021Article
- Review
- The Function ofBiology · 2020Article
- Acetamidine-Based iNOS Inhibitors as Molecular Tools to Counteract Inflammation in BV2 Microglial Cells.Molecules (Basel, Switzerland) · 2020Article
- Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities.Antioxidants & redox signaling · 2019Review
- The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells.Stem cells international · 2019Review
- Dysfunction of Cellular Proteostasis in Parkinson's Disease.Frontiers in neuroscience · 2019Review
- Real-time PCR quantification of spliced X-box binding protein 1 (XBP1) using a universal primer method.PloS one · 2019Article
- Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.Nature reviews. Drug discovery · 2018Review
- Conditioning Against the Pathology of Parkinson's disease.Conditioning medicine · 2018Article
- Evidence for cross-hemispheric preconditioning in experimental Parkinson's disease.Brain structure & function · 2018Article
- Wolfram syndrome: MAMs' connection?Cell death & disease · 2018Review
- Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents NaCell death & disease · 2018Article
- Evolvability of Amyloidogenic Proteins in Human Brain.Journal of Alzheimer's disease : JAD · 2018Article
- Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability.Journal of Huntington's disease · 2018Article
- Is age a key factor contributing to the disparity between success of neuroprotective strategies in young animals and limited success in elderly stroke patients? Focus on protein homeostasis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 19 institutions in 7 countries.
B MollereauUniv Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, F-69007, Lyon, France. Electronic address: bertrand.mollereau@ens-lyon.fr.
N M RzechorzekCentre for Clinical Brain Sciences, Chancellor's Building, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, United Kingdom.
B D RousselInserm, UMR-S U919 Serine Proteases and Pathophysiology of the Neurovascular Unit, 14000 Caen, France.
M SedruUniv Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, F-69007, Lyon, France.
D M Van den BrinkUniv Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, F-69007, Lyon, France.
B Bailly-MaitreINSERM U1065, C3M, Team 8 (Hepatic Complications in Obesity), Nice, France.
F PalladinoUniv Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, F-69007, Lyon, France.
D B MedinasBiomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Molecular Studies of the Cell, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Faculty of Medicine, University of Chile, Santiago, Chile.
P M DomingosITQB-UNL, Av. da Republica, EAN, 2780-157 Oeiras, Portugal.
S HunotInserm, U 1127, F-75013 Paris, France; CNRS, UMR 7225, F-75013 Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013 Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, F-75013 Paris, France.
S ChandranCentre for Clinical Brain Sciences, Chancellor's Building, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
S BirmanGenes Circuits Rhythms and Neuropathology, Brain Plasticity Unit, CNRS UMR 8249, ESPCI ParisTech, PSL Research University, 75005 Paris, France.
T BaronANSES, French Agency for Food, Environmental and Occupational Health & Safety, Neurodegenerative Diseases Unit, 31, avenue Tony Garnier, 69364 Lyon Cedex 07, France.
D VivienInserm, UMR-S U919 Serine Proteases and Pathophysiology of the Neurovascular Unit, 14000 Caen, France.
C B DuarteCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Faculty of Medicine, Rua Larga, and Department of Life Sciences, University of Coimbra, 3004-504 Coimbra, Portugal.
H D RyooDepartment of Cell Biology, New York University School of Medicine, New York, NY, USA.
H StellerHoward Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
F UranoWashington University School of Medicine, Department of Internal Medicine, St. Louis, MO 63110 USA.
E ChevetInserm ERL440 "Oncogenesis, Stress, Signaling", Université de Rennes 1, Rennes, France; Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France.
G KroemerEquipe 11 labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Cell Biology and Metabolomics platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France; INSERM, U1138, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie, Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Karolinska Institute, Department of Women׳s and Children׳s Health, Karolinska University Hospital, Stockholm, Sweden.
A CiechanoverThe Polak Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 30196, Israel.
E J CalabreseDepartment of Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA 01003, USA.
R J KaufmanDegenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
C HetzBiomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Molecular Studies of the Cell, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Faculty of Medicine, University of Chile, Santiago, Chile; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA.
Inserm · FRCentre Eugène Marquis · FRUniversity of Edinburgh · GBAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail · FRCenter for Climate and Resilience Research · CLCentre National de la Recherche Scientifique · FRDiscovery Institute · USÉcole Normale Supérieure de Lyon · FRHôpital Européen · FRInstitut du Cerveau · FRInstitut national de recherche en sciences et technologies du numérique · FRInstituto Português Da Qualidade · PTNew York University · USRockefeller University · USSerine Proteases and Pathophysiology of the neurovascular Unit · FRUniversité Claude Bernard Lyon 1 · FRUniversité Paris Sciences et Lettres · FRUniversity of Coimbra · PTWashington University in St. Louis · US
Funding
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1MTRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2MUnfolded Protein Response in Eye Development and DiseaseR01EY020866 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HYUNG D RYOO · 2010 to 2026
$6.9MProteasome Regulation and Function in Cellular RemodelingR01GM060124 · NIGMS · ROCKEFELLER UNIVERSITY · PI STELLER, HERMANN · 1999 to 2018
$5.4MRole of the Unfolded Protein Response in Beta CellR37DK042394 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAUFMAN, RANDAL J. · 2007 to 2016
$4.9MRegulation of ER stress-induced cell deathR01DK088227 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAUFMAN, RANDAL J. · 2010 to 2014
$3.1MENDOPLASMIC RETICULUM STRESS AND DIABETESR01DK067493 · NIDDK · WASHINGTON UNIVERSITY · PI URANO, FUMIHIKO · 2005 to 2013
$2.8MStreamlined Diagnostic Strategy for Primary AldosteronismR21DK103183 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AUCHUS, RICHARD J., RAINEY, WILLIAM E · 2015 to 2016
$426kNCATS NIH HHS UL1 TR000448NEI NIH HHS R01 EY020866NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P60 DK020579NIDDK NIH HHS R01 DK067493NIDDK NIH HHS R01 DK088227NIDDK NIH HHS R21 DK103183NIDDK NIH HHS R37 DK042394NIGMS NIH HHS R01 GM060124Wellcome TrustWellcome Trust 096409/Z/11/Z
Abstract
In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of cellular protective and repair responses, thus maintaining cell function. These interconnected adaptive mechanisms comprise a 'proteostasis network' and include the unfolded protein response, the ubiquitin proteasome system and autophagy. Interestingly, several recent studies have shown that these adaptive responses can be stimulated by preconditioning treatments, which confer resistance to a subsequent toxic challenge - the phenomenon known as hormesis. In this review we discuss the impact of adaptive stress responses stimulated in diverse human neuropathologies including Parkinson׳s disease, Wolfram syndrome, brain ischemia, and brain cancer. Further, we examine how these responses and the molecular pathways they recruit might be exploited for therapeutic gain. This article is part of a Special Issue entitled SI:ER stress.
Indexed as
AutophagyNervous System DiseasesAnimalsEndoplasmic Reticulum StressHumansProteasome Endopeptidase ComplexProteostasis DeficienciesSignal TransductionUbiquitinUnfolded Protein ResponseProteasome Endopeptidase ComplexUbiquitinAutophagyER stressGlioblastomaHormesisIschemiaParkinson׳s diseaseProteasomeWolfram syndrome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.