ArticleCell transplantation2016
A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation.
Article in Cell transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Donation After Circulatory Death Islets are Comparable to Standard-of-Care Donation After Brain Death Islets: Analysis of 801 Consecutive Human Islet Isolations.Transplantation direct · 2026Article
- Human research islet cell culture outcomes at the Alberta Diabetes Institute IsletCore.Islets · 2024Article
- Status of islet transplantation and innovations to sustainable outcomes: novel sites, cell sources, and drug delivery strategies.Frontiers in transplantation · 2024Review
- Donor Blood Tests do Not Predict Pancreas Graft Survival After Simultaneous Pancreas Kidney Transplantation; a National Cohort Study.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Donor- and isolation-related predictive factors ofFrontiers in endocrinology · 2024Article
- Continuous vs. discontinuous purification of isolated human islets: functional and morphological comparison.Frontiers in endocrinology · 2023Article
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- Clinical use of donation after circulatory death pancreas for islet transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
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- Isolated pancreatic islet yield and quality is inversely related to organ donor age in rats.Experimental gerontology · 2019Article
- Disparity in Adiposity among Adults with Normal Body Mass Index and Waist-to-Height Ratio.iScience · 2019Article
- Article
- Validation of a New North American Islet Donor Score for Donor Pancreas Selection and Successful Islet Isolation in a Medium-Volume Islet Transplant Center.Cell transplantation · 2019Article
- Pancreatic beta cell/islet mass and body mass index.Islets · 2019Article
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- Does Islet Size Really Influence Graft Function After Clinical Islet Transplantation?Transplantation · 2018Article
- Quantitative analysis of intra- and inter-individual variability of human beta-cell mass.Scientific reports · 2017Article
- Effect of Manufacturing Procedures on Human Islet Isolation From Donor Pancreata Standardized by the North American Islet Donor Score.Cell transplantation · 2017Article
- Utility of Islet Cell Preparations From Donor Pancreases After Euthanasia.Cell transplantationArticle
Corrections and comments
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Authors and funding
36 authors at 11 institutions in 2 countries.
Funding
Abstract
Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in North America to develop an islet donor scoring system using donor variables. The data set consisting of 1,056 deceased donors was used for development of a scoring system to predict islet isolation success (defined as postpurification islet yield >400,000 islet equivalents). With the aid of univariate logistic regression analyses, we developed the North American Islet Donor Score (NAIDS) ranging from 0 to 100 points. The c index in the development cohort was 0.73 (95% confidence interval 0.70-0.76). The success rate increased proportionally as the NAIDS increased, from 6.8% success in the NAIDS < 50 points to 53.7% success in the NAIDS ≥ 80 points. We further validated the NAIDS using a separate set of data consisting of 179 islet isolations. A comparable outcome of the NAIDS was observed in the validation cohort. The NAIDS may be a useful tool for donor pancreas selection in clinical practice. Apart from its utility in clinical decision making, the NAIDS may also be used in a research setting as a standardized measurement of pancreas quality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.