Evidence map›Paper›PMID 26922918›Full record

ArticleMagnetic resonance in medicine2017

A new paramagnetically shifted imaging probe for MRI.

P Kanthi Senanayake, Nicola J Rogers, Katie-Louise N A Finney, Peter Harvey, Alexander M Funk, J Ian Wilson, Dara O'Hogain, Ross Maxwell, David Parker, Andrew M Blamire

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

P Kanthi SenanayakeDept. of Chemistry, Durham University, South Road, Durham, United Kingdom.
Nicola J RogersDept. of Chemistry, Durham University, South Road, Durham, United Kingdom.
Katie-Louise N A FinneyDept. of Chemistry, Durham University, South Road, Durham, United Kingdom.
Peter HarveyDept. of Chemistry, Durham University, South Road, Durham, United Kingdom.
Alexander M FunkDept. of Chemistry, Durham University, South Road, Durham, United Kingdom.
J Ian WilsonNorthern Institute for Cancer Research, Newcastle University, United Kingdom.
Dara O'HogainInstitute of Cellular Medicine & Newcastle MR Centre, Newcastle University, United Kingdom.
Ross MaxwellNorthern Institute for Cancer Research, Newcastle University, United Kingdom.
David ParkerDept. of Chemistry, Durham University, South Road, Durham, United Kingdom.
Andrew M BlamireInstitute of Cellular Medicine & Newcastle MR Centre, Newcastle University, United Kingdom.
Durham University · GBNewcastle University · GB

Funding

Cancer Research UK 10348European Research Council 266804
6 · The paper itself

Abstract

purposeTo develop and characterize a new paramagnetic contrast agent for molecular imaging by MRI.

methodsA contrast agent was developed for direct MRI detection through the paramagnetically shifted proton magnetic resonances of two chemically equivalent tert-butyl reporter groups within a dysprosium(III) complex. The complex was characterized in phantoms and imaged in physiologically intact mice at 7 Tesla (T) using three-dimensional (3D) gradient echo and spectroscopic imaging (MRSI) sequences to measure spatial distribution and signal frequency.

resultsThe reporter protons reside ∼6.5 Å from the paramagnetic center, resulting in fast T

conclusionsThese data demonstrate a new MRI agent with the potential for physiological monitoring by MRI. Magn Reson Med 77:1307-1317, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Indexed as

AnimalsCell Line, TumorContrast MediaDysprosiumMagnetic Resonance ImagingMaterials TestingMetabolic Clearance RateMiceMice, NudeMolecular ProbesMolecular Probe TechniquesNeoplasms, ExperimentalOrgan SpecificityReproducibility of ResultsSensitivity and SpecificityTissue DistributionContrast MediaDysprosiumMolecular Probescontrast agentmolecular imagingparamagnetic shifttemperature mapping

Identifiers

PMID26922918
PMCPMC5324534
OpenAlexW2288139898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.