Evidence map›Paper›PMID 26922900›Full record

ArticleAngewandte Chemie (International ed. in English)2016

Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase.

Meixia Liu, Chun-Chi Chen, Lu Chen, Xiansha Xiao, Yingying Zheng, Jian-Wen Huang, Weidong Liu, Tzu-Ping Ko, Ya-Shan Cheng, Xinxin Feng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Biosynthesis of irregular monoterpene lavandulol inSynthetic and systems biotechnology · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Structure of undecaprenyl pyrophosphate synthase from Acinetobacter baumannii.Acta crystallographica. Section F, Structural biology communications · 2018
    Article
  9. Article
  10. Review
  11. Head-to-Head Prenyl Synthases in Pathogenic Bacteria.Chembiochem : a European journal of chemical biology · 2017
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Meixia LiuCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Chun-Chi ChenIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Lu ChenDepartment of Biochemistry, University of Illinois, Urbana, IL, 61801, USA.
Xiansha XiaoIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Yingying ZhengIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Jian-Wen HuangAsiaPac Biotechnology Co., Ltd., Dongguan, 523808, China.
Weidong LiuIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Tzu-Ping KoInstitute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.
Ya-Shan ChengIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Xinxin FengDepartment of Chemistry, University of Illinois, Urbana, IL, 61801, USA.
Eric OldfieldDepartment of Chemistry, University of Illinois, Urbana, IL, 61801, USA. eo@chad.scs.uiuc.edu.
Rey-Ting GuoIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. guo_rt@tib.cas.cn.
Yanhe MaIndustrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. ma_yh@tib.cas.cn.
Chinese Academy of Sciences · CNUniversity of Illinois Urbana-Champaign · USInstitute of Biological Chemistry, Academia Sinica · TWKai Biotech (South Korea) · KRTianjin Institute of Industrial Biotechnology · CNTianjin University of Science and Technology · CNUniversity of Illinois System · US

Funding

Structure, Function and Inhibition of [4Fe-4S] ProteinsR01GM065307 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI OLDFIELD, ERIC · 2002 to 2017
$5.4M
Next generation bisphosphonates for chemo- and immuno-therapyR01CA158191 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI OLDFIELD, ERIC · 2011 to 2015
$1.6M
NCI NIH HHS CA158191NCI NIH HHS R01 CA158191NIGMS NIH HHS GM065307NIGMS NIH HHS R01 GM065307
6 · The paper itself

Abstract

We report the first X-ray structure of the unique "head-to-middle" monoterpene synthase, lavandulyl diphosphate synthase (LPPS). LPPS catalyzes the condensation of two molecules of dimethylallyl diphosphate (DMAPP) to form lavandulyl diphosphate, a precursor to the fragrance lavandulol. The structure is similar to that of the bacterial cis-prenyl synthase, undecaprenyl diphosphate synthase (UPPS), and contains an allylic site (S1) in which DMAPP ionizes and a second site (S2) which houses the DMAPP nucleophile. Both S-thiolo-dimethylallyl diphosphate and S-thiolo-isopentenyl diphosphate bind intact to S2, but are cleaved to (thio)diphosphate, in S1. His78 (Asn in UPPS) is essential for catalysis and is proposed to facilitate diphosphate release in S1, while the P1 phosphate in S2 abstracts a proton from the lavandulyl carbocation to form the LPP product. The results are of interest since they provide the first structure and structure-based mechanism of this unusual prenyl synthase.

Indexed as

Acyclic MonoterpenesCrystallography, X-RayDimethylallyltranstransferaseModels, MolecularMonoterpenesStructure-Activity RelationshipAcyclic MonoterpenesDimethylallyltranstransferaselavandulolMonoterpenesbiosynthesisfragrancemonoterpenesnatural productsstructure elucidation

Identifiers

PMID26922900
PMCPMC4782148
OpenAlexW2279314794

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.