Evidence map›Paper›PMID 26922414›Full record

ReviewCurrent pain and headache reports2016

Fibromyalgia Pathogenesis and Treatment Options Update.

Steven Chinn, William Caldwell, Karina Gritsenko

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06378788 (Ultrasound-imaged Muscle Architecture and Muscle Strength in Fibromyalgia and it's Correlation With Pain, Disease Activity, and Functionality), which is not on this map. Cited by 127 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 6 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06378788 unknown statusnot on this mapstarted 2024, after this paper: background citation

Ultrasound-imaged Muscle Architecture and Muscle Strength in Fibromyalgia and it's Correlation With Pain, Disease Activity, and Functionality

Typeobservational_patient_registrySponsorBezmialem Vakif UniversityRan2024 to 2024Enrolled30ConditionsFibromyalgia, Sarcopenia, Muscle WeaknessArmsDemographic information form, widespread pain index (WPI), symptom severity scale (SSS), Fibromyalgia Impact Questionnaire (FIQ), Tender Point examination
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 6 syntheses or guidelines pooled it, 288 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Immediate Effects of a Telerehabilitation Program Based on Aerobic Exercise in Women with Fibromyalgia.International journal of environmental research and public health · 2021
    Trial
  10. Effects of Manual Therapy on Fatigue, Pain, and Psychological Aspects in Women with Fibromyalgia.International journal of environmental research and public health · 2020
    Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. Adjunctive D-cycloserine to intermittent theta-burst transcranial magnetic stimulation in fibromyalgia: a randomized placebo-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  17. Article
  18. Article
  19. Review
  20. Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Steven ChinnDepartment of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
William CaldwellDepartment of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Karina GritsenkoDepartment of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA. KGRITSEN@montefiore.org.
Albert Einstein College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review article presents and summarizes up-to-date literature on the clinical manifestations, diagnosis, pathophysiological mechanisms, and treatment options for fibromyalgia patients. First, the most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatology will be summarized. Clinical features, including chronic widespread pain, hyperalgesia, mood disorders, anxiety, and disturbed sleep patterns will be explored in-depth. The pathogenesis and pathophysiology of fibromyalgia involves alterations in multiple ascending and descending central nervous system pathways, as well as peripheral pathways, leading to heightened pain sensitivity. Risk factors have been studied extensively, and the most recent research focuses on various genetic influences and the contributions of stress and poor sleep. Lastly, the discussion in this article focuses on treatment options for fibromyalgia; some have been mainstay options for many years. Pharmacological agents include tricyclic antidepressants, anti-epileptic drugs, selective serotonin reuptake inhibitors, norepinephrine/serotonin reuptake inhibitors, as well as some investigational agents. The evidence behind non-pharmacologic treatments, including massage therapy, exercise, and acupuncture, are discussed.

Indexed as

FibromyalgiaHumansPain ManagementRisk FactorsCentral sensitivity syndromeFibromyalgiaFibromyalgia, acupunctureFibromyalgia, massageFibromyalgia, pathogenesisFibromyalgia, sleep disturbanceFibromyalgia, treatment

Identifiers

PMID26922414
OpenAlexW2289941121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.