Evidence map›Paper›PMID 26922333›Full record

ArticleThe journal of headache and pain2015

Altered effective connectivity of posterior thalamus in migraine with cutaneous allodynia: a resting-state fMRI study with Granger causality analysis.

Ting Wang, Ning Chen, Wang Zhan, Jia Liu, Junpeng Zhang, Qi Liu, Hua Huang, Li He, Junran Zhang, Qiyong Gong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ting WangDepartment of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, No.24, South Section One, First Ring Road, Chengdu, 610065, P.R China.
Ning ChenDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, P.R China.
Wang ZhanNeuroimaging Center, University of Maryland, College Park, MD, USA.
Jia LiuHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, P.R China.
Junpeng ZhangDepartment of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, No.24, South Section One, First Ring Road, Chengdu, 610065, P.R China.
Qi LiuDepartment of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, No.24, South Section One, First Ring Road, Chengdu, 610065, P.R China.
Hua HuangDepartment of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, No.24, South Section One, First Ring Road, Chengdu, 610065, P.R China.
Li HeDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, P.R China.
Junran ZhangDepartment of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, No.24, South Section One, First Ring Road, Chengdu, 610065, P.R China. zhangjunran@gmail.com.
Qiyong GongHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, P.R China. qiyonggong@hmrrc.org.cn.
Sichuan University · CNWest China Hospital of Sichuan University · CNUniversity of Maryland, College Park · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost migraineurs develop cutaneous allodynia (CA) during migraine, and the underlying mechanism of CA in migraine is thought to be sensitization of the third-order trigeminovascular neurons in the posterior thalamic nuclei. This study aimed to investigate whether the ascending/descending pathway associated with the thalamus is disturbed in migraineurs with CA (MWCA) using effective connectivity analysis of resting-state functional magnetic resonance imaging.

methodsThirty four migraineurs without aura (14 MWCA and 20 migraineurs without CA (MWoCA)) and 25 matched healthy controls (HC) were recruited in the study. The effective connectivity pathways associated with the posterior thalamus (PTH) were investigated using the Granger causality analysis. We chose bilateral PTH as two individual seeds, and compared MWCA with MWoCA and HC, respectively. Spearman correlation analysis was performed to test the correlation between the abnormal effective connectivity and the allodynia severity of MWCA.

resultsCompared with MWoCA, MWCA showed decreased inflows from the left limbic regions and dorsal medial prefrontal cortex (dmPFC) to the ipsilateral PTH, as well as increased inflow from the right ventral medial prefrontal cortex (vmPFC) to the ipsilateral PTH; no significantly different outflows from the bilateral PTH to other regions were found. Compared with HC, MWCA showed increased outflows from the left PTH to the bilateral vmPFC, decreased outflows from the right PTH to the bilateral temporoparietal areas, decreased inflow from the left parietooccipital area to the ipsilateral PTH, and increased inflows from the right dorsolateral prefrontal cortex and the bilateral temporoparietal areas to the right PTH. Correlation analyses revealed that the disturbed connectivities between PTH and cuneus, as well as PTH and middle frontal gyrus were associated with the allodynia severity of MWCA.

conclusionsMWCA demonstrated disrupted effective connection pathways between the PTH and other cortical or subcortical regions that participated in multi-dimentional pain processing. Our findings highlight the dysfunctional ascending and descending pain network at the thalamic-level and may help to illuminate the possible pathophysiologic mechanisms of CA.

Indexed as

AdultFemaleHumansHyperalgesiaMagnetic Resonance ImagingMaleMigraine DisordersNerve NetThalamusYoung AdultCutaneous allodyniaEffective connectivityGranger causality analysisMigrainePosterior thalamusResting-state functional magnetic resonance imaging

Identifiers

PMID26922333
PMCPMC4769706
OpenAlexW2282607829

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.