ArticleHead and neck pathology2016
Rosai-Dorfman Disease Harboring an Activating KRAS K117N Missense Mutation.
Article in Head and neck pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Rosai-Dorfman-Destombes disease of the nervous system: a systematic literature review.Orphanet journal of rare diseases · 2022Pooled it
- Molecular Mutations in Histiocytosis: A Comprehensive Survey of Genetic Alterations.Molecular biotechnology · 2025Review
- Case Report: Improvement from no light perception after radiotherapy and surgical debulking for orbital Rosai-Dorfman disease.Frontiers in ophthalmology · 2025Article
- Rosai-Dorfman-Destombes disease in adults: a single center experience.Annals of hematology · 2024Article
- Orbital histiocytosis; From A to Z.International ophthalmology · 2024Review
- Mediastinal Rosai-Dorfman Disease with KRAS mutation case report and literature review.Journal of cardiothoracic surgery · 2024Review
- Rosai-Dorfman disease of the cauda equina: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Top Ten Lymphoproliferative Lesions Not to Miss When Evaluating Oral Ulcer Biopsies.Head and neck pathology · 2023Review
- Review
- Limited sinonasal Rosai-Dorfman disease presenting as chronic sinusitis.Histopathology · 2022Article
- Rosai-Dorfman disease: A pathological experience from 2 tertiary care hospitals in Western Saudi Arabia.Saudi medical journal · 2022Article
- Rosai-Dorfman disease of the central nervous system: A clinical, radiological, and prognostic study of 12 cases.Frontiers in oncology · 2022Article
- Rosai-Dorfman disease in the central nervous system with two isolated lesions originated from a single clone: a case report.BMC neurology · 2021Article
- MAP-Kinase-Driven Hematopoietic Neoplasms: A Decade of Progress in the Molecular Age.Cold Spring Harbor perspectives in medicine · 2021Review
- NRAS Mutations May Be Involved in the Pathogenesis of Cutaneous Rosai Dorfman Disease: A Pilot Study.Biology · 2021Article
- Cerebral Infiltrative Lesion and Chronic Clinical Course of the Rosai-Dorfman Disease.Iranian journal of child neurology · 2021Article
- Rosai-Dorfman disease mimicking IgG4-related diseases: a single-center experience in China.Orphanet journal of rare diseases · 2020Article
- Rosai-Dorfman Disease-Utility of 18F-FDG PET/CT for Initial Evaluation and Follow-up.Clinical nuclear medicine · 2020Article
- Clinicopathological features, treatment approaches, and outcomes in Rosai-Dorfman disease.Haematologica · 2020Article
- [Rosai-Dorfman disease: a clinicopathologic analysis and whole exome sequencing in 23 cases].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy is a rare histiocytic proliferation that is generally considered to be reactive with a benign clinical course. The etiology of RDD is very poorly understood. Recent studies have shown frequent BRAF, NRAS, KRAS, and PIK3CA activating mutations in several histiocytic neoplasms highlighting the emerging importance of the RAF/MEK/ERK pathway in the pathogenesis of these diseases. Here we report a case of Rosai-Dorfman disease involving the submandibular salivary gland with a KRAS K117N missense mutation discovered by next-generation sequencing. These results suggest that at least a subset of RDD cases may be clonal processes. Further mutational studies on this rare histiocytic disease should be undertaken to better characterize its pathogenesis as well as open up potential avenues for therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.