Evidence map›Paper›PMID 26922057›Full record

ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016

Chondral and osteochondral operative treatment in early osteoarthritis.

Peter Angele, Philipp Niemeyer, Matthias Steinwachs, Giuseppe Filardo, Andreas H Gomoll, Elizaveta Kon, Johannes Zellner, Henning Madry

Abstract readReview
PubMed Publisher
In one paragraph

Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. No evidence for combining cartilage treatment and knee osteotomy in osteoarthritic joints: a systematic literature review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018
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  13. Cell-based regenerative joint therapy: a hot topic.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter AngeleDepartment of Trauma Surgery, University Medical Center of Regensburg, Franz-Josef Strauss Allee 11, 93042, Regensburg, Germany. peter.angele@ukr.de.
Philipp NiemeyerDepartment of Orthopedic Surgery and Traumatology, Freiburg University Hospital, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Matthias SteinwachsSportClinic Zurich, Hirslandenklinik, Witellikerstrasse 40, 8032, Zurich, Switzerland.
Giuseppe FilardoBiomechanics Laboratory, II Orthopaedics and Traumatology Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136, Bologna, Italy.
Andreas H GomollDepartment of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Elizaveta KonBiomechanics Laboratory, II Orthopaedics and Traumatology Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136, Bologna, Italy.
Johannes ZellnerDepartment of Trauma Surgery, University Medical Center of Regensburg, Franz-Josef Strauss Allee 11, 93042, Regensburg, Germany.
Henning MadryCenter of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years treatment of early osteoarthritis came more and more into focus of orthopaedic research. In particular regenerative therapy options seem to have a high potential to fill the existing treatment gap for patients with early osteoarthritic changes. This article focuses on basic science, recent developments and available clinical data in the important field of operative regeneration procedures for treatment of chondral and osteochondral defects in early degenerative joints. It highlights current knowledge and perspectives of treatment options like microfracture, autologous or allogenous osteochondral transplantations and autologous chondrocyte transplantation. Further the role of biomaterials in a degenerative joint environment is illuminated. First clinical data of regenerative therapy in early osteoarthritis are encouraging to intensify research efforts in this important field. Future treatment perspectives for patients who suffer from early degenerative cartilage changes are discussed.

Indexed as

RegenerationCartilageCartilage, ArticularChondrocytesHumansOsteoarthritisTransplantation, AutologousTransplantation, HomologousAllograftsAutologous chondrocyte transplantationBiomaterialsEarly osteoarthritisMicrofractureOsteochondral autograftsRegenerative cartilage treatment

Identifiers

PMID26922057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.