ArticleAmerican journal of ophthalmology2016
Persistently Vitreous Culture-Positive Exogenous Bacterial Endophthalmitis.
Article in American journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Areas of uncertainty in endophthalmitis care.World journal of clinical cases · 2026Review
- Blepharitis driven by microbiome dysbiosis andFrontiers in medicine · 2026Review
- [Distribution and Antibiotic Resistance Analysis of Ocular Bacterial Pathogens at a Tertiary Hospital From 2012 to 2021].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Application Progress of High-Throughput Sequencing in Ocular Diseases.Journal of clinical medicine · 2022Review
- Early and complete vitrectomy versus tap and inject in acute post cataract surgery endophthalmitis presenting with hand motion vision; a quasi-experimental study.BMC ophthalmology · 2022Article
- Endophthalmitis at a tertiary referral center: Characteristics and treatment outcomes over three decades.Frontiers in cell and developmental biology · 2022Article
- Atypical Microbiological Feature of Infectious Endophthalmitis on Jeju Island: A 10-Year Study at a Single Tertiary Referral Center.Journal of ophthalmology · 2021Article
- Ocular bacterial infections at a tertiary eye center in China: a 5-year review of pathogen distribution and antibiotic sensitivity.International journal of ophthalmology · 2020Article
- A presumed iridocyclitis developed to panophthalmitis caused by a non-metallic intraocular foreign body.International journal of ophthalmology · 2019Article
- Trends in treatment strategies for suspected bacterial endophthalmitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Article
- Clinical Practice Update: Management of Infectious Endophthalmitis After Intravitreal Anti-VEGF Injection.Journal of vitreoretinal diseasesReview
- Repeat Intraocular Sampling and Microbiological Testing in Infectious Endophthalmitis: A 27-Year Prospective Observational Study at an Australian Statewide Tertiary Referral Centre.Clinical & experimental ophthalmologyObservational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo report the clinical settings, bacterial isolates, antibiotic sensitivities, and visual acuity outcomes of patients with persistently positive vitreous cultures after intravitreal antibiotics.
designConsecutive, noncomparative case series.
methodssetting: Tertiary care center. PATIENT POPULATION: Thirty-six eyes of 36 patients with exogenous endophthalmitis with the same bacterial organism identified on at least 2 consecutive vitreous cultures from 1981 to 2015. OBSERVATION PROCEDURES: Vitreous cultures with intravitreal injections of antibiotics and pars plana vitrectomies with intravitreal antibiotics.
main outcome measuresBacterial isolates, antibiotic sensitivities, visual outcomes.
resultsThirty-six eyes of 36 patients met the study criteria. The mean follow-up was 26.5 months. The most common clinical settings were after cataract extraction (18/36, 50%) and glaucoma surgery (11/36, 31%). The mean initial visual acuity was 2.16 ± 0.77 logMAR (Snellen equivalent ≈20/2900), and there was no statistically significant change at the final evaluation (2.08 ± 0.97 logMAR, ≈20/1900, P = .72). The most common bacteria were Staphylococcus (11/36, 31%) and Streptococcus (9/36, 25%). Gram-positive bacteria were sensitive to vancomycin (27/27, 100%); gram-negative bacteria were sensitive to amikacin (5/5, 100%). The antibiotic sensitivities were the same on repeat cultures in 34 of 36 patients (94%). The initial treatment was a vitreous culture and intravitreal injection of antibiotics in 28 of 36 patients (78%). The vision at the last follow-up was 20/200 or better in 12 patients (33%) and no light perception in 11 of 36 patients (31%).
conclusionsThe most commonly identified organisms were gram-positive bacteria. There was good concordance in the antibiotic sensitivities between initial and subsequent cultures. Patients with persistently vitreous culture-positive endophthalmitis had poor visual outcomes.
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