ReviewCurrent opinion in biotechnology2016
Biomaterials approaches to modeling macrophage-extracellular matrix interactions in the tumor microenvironment.
Review in Current opinion in biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- CaMKK2 Regulates Macrophage Polarization Induced by Matrix Stiffness: Implications for Shaping the Immune Response in Stiffened Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Molecular Mechanism of Macrophages in Response to Mechanical Stress.Annals of biomedical engineering · 2025Review
- Data driven and biophysical insights into the regulation of trafficking vesicles by extracellular matrix stiffness.iScience · 2022Article
- Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction.International journal of molecular sciences · 2021Review
- Directionality of Macrophages Movement in Tumour Invasion: A Multiscale Moving-Boundary Approach.Bulletin of mathematical biology · 2020Article
- Disease-inspired tissue engineering: Investigation of cardiovascular pathologies.ACS biomaterials science & engineering · 2020Review
- Biomaterials-Mediated Regulation of Macrophage Cell Fate.Frontiers in bioengineering and biotechnology · 2020Review
- Directing toll-like receptor signaling in macrophages to enhance tumor immunotherapy.Current opinion in biotechnology · 2019Review
- Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix.Nature communications · 2019Article
- Biomechanical forces in tissue engineered tumor models.Current opinion in biomedical engineering · 2018Article
- [Progress on cancer associated fibroblasts in tumor immunoregulation].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Review
- Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer.Oncotarget · 2017Article
- shRNA-mediated downregulation of α-N-Acetylgalactosaminidase inhibits migration and invasion of cancer cell lines.Iranian journal of basic medical sciences · 2017Article
- Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy.Cancer immunology, immunotherapy : CII · 2017Review
- Effects of age-related shifts in cellular function and local microenvironment upon the innate immune response to implants.Seminars in immunology · 2017Review
- Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression.Convergent science physical oncology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tumors are characterized by aberrant extracellular matrix (ECM) remodeling and chronic inflammation. While advances in biomaterials and tissue engineering strategies have led to important new insights regarding the role of ECM composition, structure, and mechanical properties in cancer in general, the functional link between these parameters and macrophage phenotype is poorly understood. Nevertheless, increasing experimental evidence suggests that macrophage behavior is similarly controlled by physicochemical properties of the ECM and consequential changes in mechanosignaling. Here, we will summarize the current knowledge of macrophage biology and ECM-mediated differences in mechanotransduction and discuss future opportunities of biomaterials and tissue engineering platforms to interrogate the functional relationship between these parameters and their relevance to cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.