ArticleAddictive behaviors2016
The impact of non-concordant self-report of substance use in clinical trials research.
Article in Addictive behaviors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Imagining the future can shape the present: A systematic review of the impact of episodic future thinking on substance use outcomes.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024Pooled it
- Proposing a "Brain Health Checkup (BHC)" as a Global Potential "Standard of Care" to Overcome Reward Dysregulation in Primary Care Medicine: Coupling Genetic Risk Testing and Induction of "Dopamine Homeostasis".International journal of environmental research and public health · 2022Pooled it
- Drug Use Disorders and Violence: Associations With Individual Drug Categories.Epidemiologic reviews · 2020Pooled it
- Self-report and urine drug screen concordance among women with co-occurring PTSD and substance use disorders participating in a clinical trial: Impact of drug type and participant characteristics.Drug and alcohol dependence · 2023Trial
- Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with men who binge drink alcohol.Alcoholism, clinical and experimental research · 2022Trial
- Trajectory classes of opioid use among individuals in a randomized controlled trial comparing extended-release naltrexone and buprenorphine-naloxone.Drug and alcohol dependence · 2019Trial
- Correlates of Validity of Self-Reported Methamphetamine Use among a Sample of Dependent Adults.Substance use & misuse · 2018Trial
- Development of a nomogram for prediction of postoperative bleeding after transurethral resection of bladder tumors.International urology and nephrology · 2026Article
- From Diagnosis to Behaviour Change: Applying the Health Action Process Approach to Smoking Cessation After Head and Neck Cancer.Behavioral sciences (Basel, Switzerland) · 2026Article
- Using a quality improvement framework to evaluate the feasibility of implementing a patient-reported outcome measure for recovery in an office-based treatment setting for opioid use disorder.Addiction science & clinical practice · 2025Article
- Comparison of Self-Reported Substance Use with Outcomes of Urine Testing among Men Who Have Sex with Men in Africa Participating in HPTN 075.AIDS and behavior · 2025Observational
- Estimating the population size of people who inject drugs in Canada, 2021.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025Review
- An Examination of Objective and Self-Report Measures of Ad Libitum Electronic Cigarette Use: Identifying Patterns of Puffing Behavior and Evaluating Self-Report Items.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Objective Identification of Cannabis Use Levels in Clinical Populations Is Critical for Detecting Pharmacological Outcomes.Cannabis and cannabinoid research · 2022Article
- Association between spine injury and opioid misuse in a prospective cohort of Level I trauma patients.OTA international : the open access journal of orthopaedic trauma · 2022Article
- Validity of self-reported substance use: research setting versus primary health care setting.Substance abuse treatment, prevention, and policy · 2021Article
- Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.Exploration of medicine · 2021Article
- Nicotine and Toxicant Exposure Among Concurrent Users (Co-Users) of Tobacco and Cannabis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Vertebral Artery Dissection Related to Amphetamine Abuse - A Case Report.Journal of central nervous system disease · 2020Article
- What happens to agreement over time? A longitudinal study of self-reported substance use compared to saliva toxicological testing among subsidized housing residents.Journal of substance abuse treatment · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStudies comparing self-report substance use data to biochemical verification generally demonstrate high rates of concordance. We argue that these rates are due to the relatively high true negative rate in the general population, and high degree of honestly in treatment seeking individuals. We hypothesized that high risk individuals not seeking treatment would demonstrate low concordance and a high false negative rate of self-reported substance use.
methodsA sample of 500 individuals from a smoking cessation clinical trial was assessed over 1 year. Assessments included semi-structured interviews, questionnaires (e.g. Addiction Severity Index, etc.), and urine drug screen assays (UDS). Generalized estimating equations (GEEs) were used to predict false negative reports for various substances across the study and determine the influence of substance use on the primary study outcome of smoking cessation.
resultsParticipants demonstrated high false negative rates in reporting substances use, and the false negative rates increased as the study progressed. Established predictors of false negatives generalized to the current sample. High concordance and low false negative rates were found in self-report of nicotine use. A small but significant relationship was found in for effect of biochemically verified substance use on smoking cessation.
conclusionsBiochemical verification of substance use is needed in high risk populations involved in studies not directly related to the treatment of substance use, especially in populations with high threat of stigmatization. Testing should continue through the time period of the study for maximal identification of substance use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.