ArticleApplied and environmental microbiology2016
Relationship of Enhanced Butyrate Production by Colonic Butyrate-Producing Bacteria to Immunomodulatory Effects in Normal Mice Fed an Insoluble Fraction of Brassica rapa L.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies.International journal of molecular sciences · 2024Review
- Immunomodulatory Effects of a Probiotic Mixture: Alleviating Colitis in a Mouse Model through Modulation of Cell Activation Markers and the Gut Microbiota.International journal of molecular sciences · 2024Article
- Utilization of pomegranate and black grape seed by-products in yogurt production: Effects on phenolic compounds and antioxidant activity.Food science & nutrition · 2024Article
- Mechanisms of interleukin-10 induction in murine spleen and RAW264 cells byBioscience of microbiota, food and health · 2024Article
- Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease.Nutrients · 2023Review
- Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate.Nature communications · 2022Article
- Treatment with Distinct Antibiotic Classes Causes Different Pulmonary Outcomes on Allergic Airway Inflammation Associated with Modulation of Symbiotic Microbiota.Journal of immunology research · 2022Article
- Prospects for clinical applications of butyrate-producing bacteria.World journal of clinical pediatrics · 2021Review
- Dietary Supplementation with FermentedNutrients · 2021Article
- Alterations in intestinal microbiota diversity, composition, and function in patients with sarcopenia.Scientific reports · 2021Article
- Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota.The Journal of nutritional biochemistry · 2020Review
- A Health-Conscious Food Pattern Is Associated with Prediabetes and Gut Microbiota in the Malmö Offspring Study.The Journal of nutrition · 2020Article
- Stool sampling and DNA isolation kits affect DNA quality and bacterial composition following 16S rRNA gene sequencing using MiSeq Illumina platform.Scientific reports · 2019Article
- Microbiota Metabolite Butyrate Differentially Regulates Th1 and Th17 Cells' Differentiation and Function in Induction of Colitis.Inflammatory bowel diseases · 2019Article
- Characterization of Microbiota that Influence Immunomodulatory Effects of Fermented Brassica rapa L.Microbes and environments · 2019Article
- Exploring the microbiota and metabolites of traditional rice beer varieties of Assam and their functionalities.3 Biotech · 2019Article
- Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa.BMC genomics · 2018Article
- Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome.Nature genetics · 2018Article
- Bioactive compounds from regular diet and faecal microbial metabolites.European journal of nutrition · 2018Article
- Comparison of Fecal Collection Methods for Microbiome and Metabolomics Studies.Frontiers in cellular and infection microbiology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was performed to determine the effects of feeding a fiber-rich fraction of Brassica vegetables on the immune response through changes in enteric bacteria and short-chain fatty acid (SCFA) production in normal mice. The boiled-water-insoluble fraction of Brassica rapa L. (nozawana), which consists mainly of dietary fiber, was chosen as a test material. A total of 31 male C57BL/6J mice were divided into two groups and housed in a specific-pathogen-free facility. The animals were fed either a control diet or the control diet plus the insoluble B. rapa L. fraction for 2 weeks and sacrificed to determine microbiological and SCFA profiles in lower-gut samples and immunological molecules. rRNA-based quantification indicated that the relative population of Bacteroidetes was markedly lower in the colon samples of the insoluble B. rapa L. fraction-fed group than that in the controls. Populations of the Eubacterium rectale group and Faecalibacterium prausnitzii, both of which are representative butyrate-producing bacteria, doubled after 2 weeks of fraction intake, accompanying a marginal increase in the proportion of colonic butyrate. In addition, feeding with the fraction significantly increased levels of the anti-inflammatory cytokine interleukin-10 (IL-10) and tended to increase splenic regulatory T cell numbers but significantly reduced the population of cells expressing activation markers. We demonstrated that inclusion of the boiled-water-insoluble fraction of B. rapa L. can alter the composition of the gut microbiota to decrease the numbers of Bacteroidetes and to increase the numbers of butyrate-producing bacteria, either of which may be involved in the observed shift in the production of splenic IL-10.
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