Evidence map›Paper›PMID 26921232›Full record

ArticleEuropean child & adolescent psychiatry2016

Attenuated psychotic and basic symptom characteristics in adolescents with ultra-high risk criteria for psychosis, other non-psychotic psychiatric disorders and early-onset psychosis.

Nella Lo Cascio, Riccardo Saba, Marta Hauser, Ditte Lammers Vernal, Aseel Al-Jadiri, Yehonatan Borenstein, Eva M Sheridan, Taishiro Kishimoto, Marco Armando, Stefano Vicari and 10 more

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In one paragraph

Article in European child & adolescent psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. The Critical Need for Help-Seeking Controls in Clinical High-Risk Research.Clinical psychological science : a journal of the Association for Psychological Science · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nella Lo CascioDepartment of Neurosciences and Neurorehabilitation, Bambino Gesù Children's Hospital, Rome, Italy.
Riccardo SabaDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
Marta HauserThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
Ditte Lammers VernalResearch Unit for Child and Adolescent Psychiatry, Aalborg University Hospital, North Denmark Region, Denmark.
Aseel Al-JadiriThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
Yehonatan BorensteinThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
Eva M SheridanThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
Taishiro KishimotoThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
Marco ArmandoDepartment of Neurosciences and Neurorehabilitation, Bambino Gesù Children's Hospital, Rome, Italy.
Stefano VicariDepartment of Neurosciences and Neurorehabilitation, Bambino Gesù Children's Hospital, Rome, Italy.
Paolo Fiori NastroDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
Paolo GirardiDepartment of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy.
Eva GebhardtDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
John M KaneThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
Andrea AutherThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
Ricardo E CarriónThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
Barbara A CornblattThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
Benno G SchimmelmannUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Frauke Schultze-LutterUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Christoph U CorrellThe Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA. ccorrell@lij.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While attenuated psychotic symptoms (APS) and basic symptoms (BS) are the main current predictors of psychosis in adults, studies in adolescents are scarce. Thus, we (1) described the prevalence and severity of positive, negative, disorganization, general, and basic symptoms in adolescent patients at ultra-high risk for psychosis (UHR), with other non-psychotic psychiatric disorders (PC) and with early-onset psychosis (EOP); and (2) investigated BS criteria in relation to UHR criteria. Sixty-nine 12-18-year-old adolescents (15.3 ± 1.7 years, female = 58.0 %, UHR = 22, PC = 27, EOP = 20) were assessed with the structured interview for prodromal syndromes (SIPS) and the schizophrenia proneness instrument-child and youth version (SPI-CY). Despite similar current and past 12-month global functioning, both UHR and EOP had significantly higher SIPS total and subscale scores compared to PC, with moderate-large effect sizes. Expectedly, UHR had significantly lower SIPS positive symptom scores than EOP, but similar SIPS negative, disorganized, and general symptom scores. Compared to PC, both EOP and UHR had more severe basic thought and perception disturbances, and significantly more often met cognitive disturbances criteria (EOP = 50.0 %, UHR = 40.9 %, PC = 14.8 %). Compared to UHR, both EOP and PC significantly less often met cognitive-perceptive BS criteria (EOP = 35.0 %, UHR = 68.2 %, PC = 25.9 %). BS were significantly more prevalent in both EOP and UHR than PC, and UHR were similar to EOP in symptom domains. Given the uncertain outcome of adolescents at clinical high-risk of psychosis, future research is needed to determine whether the combined assessment of early subjective disturbances with observable APS can improve the accuracy of psychosis prediction.

Indexed as

Prodromal SymptomsAdolescentChildCognition DisordersFemaleHumansMalePsychiatric Status Rating ScalesPsychotic DisordersRisk FactorsSchizophreniaSymptom AssessmentAdolescentsBasic symptomsEarly detectionEarly-onset psychosisUltra-high risk

Identifiers

PMID26921232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.