Evidence map›Paper›PMID 26920883›Full record

ReviewJournal of microbiology (Seoul, Korea)2016

Recent advances in the understanding of the Aspergillus fumigatus cell wall.

Mark J Lee, Donald C Sheppard

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of microbiology (Seoul, Korea), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 80 citations in OpenAlex.

  1. α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in anJournal of the American Chemical Society · 2026
    Article
  2. Biomarkers in the Diagnosis of Aspergillosis.Journal of fungi (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. The postbiotic potential ofFrontiers in microbiology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. SfgA RendersJournal of fungi (Basel, Switzerland) · 2022
    Article
  12. Article
  13. Distinct Cohorts ofFrontiers in cellular and infection microbiology · 2022
    Article
  14. Solid-state NMR analysis of unlabeled fungal cell walls fromJournal of structural biology: X · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mark J LeeDepartments of Medicine, Microbiology and Immunology, McGill University, Montréal, Québec, Canada. mark.lee2@mail.mcgill.ca.
Donald C SheppardDepartments of Medicine, Microbiology and Immunology, McGill University, Montréal, Québec, Canada.
McGill University · CAMcGill University Health Centre · CA

Funding

Transcriptional regulation of A. fumigatus virulenceR01AI073829 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G · 2007 to 2015
$2.8M
Canadian Institutes of Health Research 13337Canadian Institutes of Health Research 236182NIAID NIH HHS R01AI073829
6 · The paper itself

Abstract

Over the past several decades, research on the synthesis and organization of the cell wall polysaccharides of Aspergillus fumigatus has expanded our knowledge of this important fungal structure. Besides protecting the fungus from environmental stresses and maintaining structural integrity of the organism, the cell wall is also the primary site for interaction with host tissues during infection. Cell wall polysaccharides are important ligands for the recognition of fungi by the innate immune system and they can mediate potent immunomodulatory effects. The synthesis of cell wall polysaccharides is a complicated process that requires coordinated regulation of many biosynthetic and metabolic pathways. Continuous synthesis and remodeling of the polysaccharides of the cell wall is essential for the survival of the fungus during development, reproduction, colonization and invasion. As these polysaccharides are absent from the human host, these biosynthetic pathways are attractive targets for antifungal development. In this review, we present recent advances in our understanding of Aspergillus fumigatus cell wall polysaccharides, including the emerging role of cell wall polysaccharides in the host-pathogen interaction.

Indexed as

AnimalsAspergillosisAspergillus fumigatusCell WallHost-Pathogen InteractionsHumansPolysaccharidesPolysaccharidesAspergillus fumigatusbiofilmcell wallglycobiologypolysaccharide

Identifiers

PMID26920883
OpenAlexW2337206086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.