Evidence map›Paper›PMID 26920878›Full record

ReviewJournal of microbiology (Seoul, Korea)2016

Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans.

Lois M Douglas, James B Konopka

Abstract readReview
In one paragraph

Review in Journal of microbiology (Seoul, Korea), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
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  5. UV-Induced Mutants ofJournal of fungi (Basel, Switzerland) · 2025
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  6. The Antifungal Effects of Equol AgainstJournal of fungi (Basel, Switzerland) · 2025
    Article
  7. Review
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  9. Ire1 inhibitors attenuateFrontiers in microbiology · 2025
    Article
  10. Review
  11. Regulation of yeast polarized exocytosis by phosphoinositide lipids.Cellular and molecular life sciences : CMLS · 2024
    Review
  12. Article
  13. Emerging Roles of Exocyst Complex in Fungi: A Review.Journal of fungi (Basel, Switzerland) · 2024
    Review
  14. Sur7 mediates a novel pathway for PIMolecular biology of the cell · 2024
    Article
  15. Article
  16. Hinokitiol inhibitsFrontiers in microbiology · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lois M DouglasDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, 11794-5222, USA.
James B KonopkaDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, 11794-5222, USA. james.konopka@stonybrook.edu.
Stony Brook University · US

Funding

Regulation of Morphogenesis in C. albicansR01AI047837 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI James B Konopka · 2001 to 2026
$8.8M
C. albicans invasive growth promotes oropharyngeal infectionsR21DE025200 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI KONOPKA, JAMES B · 2015 to 2016
$435k
NIAID NIH HHS R01 AI047837NIAID NIH HHS R01AI047837NIDCR NIH HHS R21 DE025200NIDCR NIH HHS R21DE025200
6 · The paper itself

Abstract

Candida albicans is a human fungal pathogen capable of causing lethal systemic infections. The plasma membrane plays key roles in virulence because it not only functions as a protective barrier, it also mediates dynamic functions including secretion of virulence factors, cell wall synthesis, invasive hyphal morphogenesis, endocytosis, and nutrient uptake. Consistent with this functional complexity, the plasma membrane is composed of a wide array of lipids and proteins. These components are organized into distinct domains that will be the topic of this review. Some of the plasma membrane domains that will be described are known to act as scaffolds or barriers to diffusion, such as MCC/eisosomes, septins, and sites of contact with the endoplasmic reticulum. Other zones mediate dynamic processes, including secretion, endocytosis, and a special region at hyphal tips that facilitates rapid growth. The highly organized architecture of the plasma membrane facilitates the coordination of diverse functions and promotes the pathogenesis of C. albicans.

Indexed as

Candida albicansCandidiasisCell MembraneEndocytosisFungal ProteinsHumansHyphaeModels, MolecularVirulenceVirulence FactorsFungal ProteinsVirulence FactorsCandida albicanseisosomefungal pathogenesishyphal morphogenesisMCC domainplasma membraneseptin

Identifiers

PMID26920878
PMCPMC5650914
OpenAlexW2341449973

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.