ArticleGenetics2016
Host Mitochondrial Association Evolved in the Human Parasite Toxoplasma gondii via Neofunctionalization of a Gene Duplicate.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The parasitophorous vacuole membrane of Toxoplasma gondii: A custom structural framing with smart interior plumbing for resource allocation.PLoS pathogens · 2026Review
- Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection.Nature microbiology · 2025Article
- Mitochondria of a human skeletal muscle cell line associate with the parasitophorous vacuoles of three archetypal lineages ofFEMS microbes · 2025Article
- Host-Parasite Interactions inInternational journal of molecular sciences · 2024Article
- Susceptibility ofmBio · 2024Article
- Toxoplasma gondii mitochondrial association factor 1b interactome reveals novel binding partners including Ral GTPase accelerating protein α1.The Journal of biological chemistry · 2024Article
- Article
- Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction.PLoS pathogens · 2022Article
- Host cell proteins modulated upon Toxoplasma infection identified using proteomic approaches: a molecular rationale.Parasitology research · 2022Review
- Third-generation sequencing revises the molecular karyotype forGenome research · 2021Article
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- Article
- Article
- Translocation of effector proteins into host cells by Toxoplasma gondii.Current opinion in microbiology · 2019Review
- Article
- Effector variation at tandem gene arrays in tissue-dwelling coccidia: who needs antigenic variation anyway?Current opinion in microbiology · 2018Review
- Comprehensive Characterization ofmBio · 2018Article
- Article
- A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions.Molecular microbiology · 2018Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In Toxoplasma gondii, an intracellular parasite of humans and other animals, host mitochondrial association (HMA) is driven by a gene family that encodes multiple mitochondrial association factor 1 (MAF1) proteins. However, the importance of MAF1 gene duplication in the evolution of HMA is not understood, nor is the impact of HMA on parasite biology. Here we used within- and between-species comparative analysis to determine that the MAF1 locus is duplicated in T. gondii and its nearest extant relative Hammondia hammondi, but not another close relative, Neospora caninum Using cross-species complementation, we determined that the MAF1 locus harbors multiple distinct paralogs that differ in their ability to mediate HMA, and that only T. gondii and H. hammondi harbor HMA(+) paralogs. Additionally, we found that exogenous expression of an HMA(+) paralog in T. gondii strains that do not normally exhibit HMA provides a competitive advantage over their wild-type counterparts during a mouse infection. These data indicate that HMA likely evolved by neofunctionalization of a duplicate MAF1 copy in the common ancestor of T. gondii and H. hammondi, and that the neofunctionalized gene duplicate is selectively advantageous.
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