ReviewJournal of molecular evolution2016
Constraints, Trade-offs and the Currency of Fitness.
Review in Journal of molecular evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Diverse drought responses and evidence for stress priming in glacier-fed stream bacteria.Frontiers in microbiology · 2026Article
- How aging causes osteoarthritis: An evolutionary physiology perspective.Osteoarthritis and cartilage · 2025Review
- Costs of reproduction in flowering plants.The New phytologist · 2025Review
- Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440.Microbial biotechnology · 2025Article
- Biological constraint, evolutionary spandrels and antagonistic pleiotropy.Ageing research reviews · 2024Review
- Early Life History Divergence Mediates Elevational Adaptation in a Perennial Alpine Plant.Ecology and evolution · 2024Article
- Patterns of sexual dimorphism in the armoured tardigrades.Biology letters · 2024Article
- Correlated responses to selection across diverse environments during experimental evolution ofEcology and evolution · 2024Article
- Understanding cellular growth strategies via optimal control.Journal of the Royal Society, Interface · 2023Article
- Phylogenetic and environmental patterns of sex differentiation in physiological traits across Drosophila species.Journal of evolutionary biology · 2022Article
- Evolving Perspective on the Origin and Diversification of Cellular Life and the Virosphere.Genome biology and evolution · 2022Review
- The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm.Ageing research reviews · 2021Review
- A genotypic trade-off between constitutive resistance to viral infection and host growth rate.Evolution; international journal of organic evolution · 2018Article
- The Life and Times of Parasites: Rhythms in Strategies for Within-host Survival and Between-host Transmission.Journal of biological rhythms · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding evolutionary trajectories remains a difficult task. This is because natural evolutionary processes are simultaneously affected by various types of constraints acting at the different levels of biological organization. Of particular importance are constraints where correlated changes occur in opposite directions, called trade-offs. Here we review and classify the main evolutionary constraints and trade-offs, operating at all levels of trait hierarchy. Special attention is given to life history trade-offs and the conflict between the survival and reproduction components of fitness. Cellular mechanisms underlying fitness trade-offs are described. At the metabolic level, a linear trade-off between growth and flux variability was found, employing bacterial genome-scale metabolic reconstructions. Its analysis indicates that flux variability can be considered as the currency of fitness. This currency is used for fitness transfer between fitness components during adaptations. Finally, a discussion is made regarding the constraints which limit the increase in the amount of fitness currency during evolution, suggesting that occupancy constraints are probably the main restrictions.
Indexed as
Identifiers
26920684What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.