Evidence map›Paper›PMID 26920654›Full record

ArticleNeurogastroenterology and motility2016

Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study.

B Bonaz, V Sinniger, D Hoffmann, D Clarençon, N Mathieu, C Dantzer, L Vercueil, C Picq, C Trocmé, P Faure and 2 more

3 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 280 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
280citing papers in PubMed, 6 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04100486 enrolling by invitationnot on this mapstarted 2019, after this paper: background citation

A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals

TypeobservationalSponsorNorthwell HealthRan2019 to 2027Enrolled48ConditionsAutonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic DisorderArmsStanding-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver
NCT04514627 nacompletednot on this mapstarted 2020, after this paper: background citation

Neuromodulation With Percutaneous Electrical Nerve Field Stimulation for Adults With COVID-19

TypeinterventionalSponsorOlive View-UCLA Education & Research InstituteRan2020 to 2022Enrolled55ConditionsCOVID-19ArmsAuricular percutaneous neurostimulation
NCT06553053 narecruitingnot on this mapstarted 2024, after this paper: background citation

Acupuncture Reduces Relapse in Patients With Crohn's Disease: a Superiority Trial

TypeinterventionalSponsorShanghai Institute of Acupuncture, Moxibustion and MeridianRan2024 to 2028Enrolled106ConditionsCrohn's Disease Relapse, Inflammatory Bowel DiseasesArms"Harmonizing Shaoyang, nourishing spleen and kidney with warmth" Acupuncture Group, "Nourishing spleen and kidney with warmth" Acupuncture Group
3 · Its place in the literature

Who cites it

280 citing papers in PubMed, 6 syntheses or guidelines pooled it, 488 citations in OpenAlex.

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220 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

B BonazUniversity Clinic of Hepato-Gastroenterology, University Hospital, Grenoble, France.
V SinnigerUniversity Clinic of Hepato-Gastroenterology, University Hospital, Grenoble, France.
D HoffmannDepartment of Neurosurgery, University Hospital, Grenoble, France.
D ClarençonStress and Neuro-Digestive Interactions, Inserm U1216, Institute of Neurosciences, University Grenoble Alpes, Grenoble, France.
N MathieuUniversity Clinic of Hepato-Gastroenterology, University Hospital, Grenoble, France.
C DantzerDepartment of Psychology, Savoie University, LIP/PC2S, Chambéry, France.
L VercueilDepartment of Neurology, University Hospital, Grenoble, France.
C PicqStress and Neuro-Digestive Interactions, Inserm U1216, Institute of Neurosciences, University Grenoble Alpes, Grenoble, France.
C TrocméInstitute of Biology and Pathology, Laboratory of Protein and Enzyme Biochemistry, University Hospital, Grenoble, France.
P FaureInstitute of Biology and Pathology, Inserm U1042, HP2, University Hospital, Grenoble, France.
J-L CracowskiInserm CIC1406, Clinical Pharmacology Department, University Hospital, Grenoble, France.
S PellissierStress and Neuro-Digestive Interactions, Inserm U1216, Institute of Neurosciences, University Grenoble Alpes, Grenoble, France.
Université Grenoble Alpes · FRCentre Hospitalier Universitaire de Grenoble · FRInserm · FRInstitute of Protein Biochemistry · ITUniversité Savoie Mont Blanc · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vagus nerve (VN) is a link between the brain and the gut. The VN is a mixed nerve with anti-inflammatory properties through the activation of the hypothalamic-pituitary-adrenal axis by its afferents and by activating the cholinergic anti-inflammatory pathway through its efferents. We have previously shown that VN stimulation (VNS) improves colitis in rats and that the vagal tone is blunted in Crohn's disease (CD) patients. We thus performed a pilot study of chronic VNS in patients with active CD. Seven patients under VNS were followed up for 6 months with a primary endpoint to induce clinical remission and a secondary endpoint to induce biological (CRP and/or fecal calprotectin) and endoscopic remission and to restore vagal tone (heart rate variability). Vagus nerve stimulation was feasible and well-tolerated in all patients. Among the seven patients, two were removed from the study at 3 months for clinical worsening and five evolved toward clinical, biological, and endoscopic remission with a restored vagal tone. These results provide the first evidence that VNS is feasible and appears as an effective tool in the treatment of active CD.

Indexed as

AdultCrohn DiseaseFemaleFollow-Up StudiesHumansMaleMiddle AgedPilot ProjectsVagus Nerve StimulationYoung Adultcholinergic anti-inflammatory pathwayCrohn's diseaseheart rate variabilityvagus nervevagus nerve stimulation

Identifiers

PMID26920654
OpenAlexW2285989687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.