Evidence map›Paper›PMID 26920578›Full record

Observational studyBMC psychiatry2016

Clinical characteristics of patients assessed within an Improving Access to Psychological Therapies (IAPT) service: results from a naturalistic cohort study (Predicting Outcome Following Psychological Therapy; PROMPT).

Nilay Hepgul, Sinead King, Myanthi Amarasinghe, Gerome Breen, Nina Grant, Nick Grey, Matthew Hotopf, Paul Moran, Carmine M Pariante, André Tylee and 3 more

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05214417 (Conscious Dying/Conscious Living), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05214417 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care

TypeinterventionalSponsorThe Ketamine Research FoundationRan2022 to 2024Enrolled120ConditionsIllness TerminalArmsKetamine Injectable Solution, Naturalistic Control
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

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  14. Care pathways for people with major depressive disorder: a European Brain Council Value of Treatment study.European psychiatry : the journal of the Association of European Psychiatrists · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Nilay HepgulDepartment of Psychological Medicine & Centre for Affective Disorders, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK. nilay.hepgul@kcl.ac.uk.
Sinead KingDepartment of Psychological Medicine & Centre for Affective Disorders, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK. sinead.king@kcl.ac.uk.
Myanthi AmarasingheKing's College London, Institute of Psychiatry, Psychology & Neuroscience, MRC Social, Genetic, and Developmental Psychiatry Centre, London, UK. myanthi.amarasinghe@kcl.ac.uk.
Gerome BreenKing's College London, Institute of Psychiatry, Psychology & Neuroscience, MRC Social, Genetic, and Developmental Psychiatry Centre, London, UK. gerome.breen@kcl.ac.uk.
Nina GrantDepartment of Psychology, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK. nina.grant@kcl.ac.uk.
Nick GreySouth London & Maudsley NHS Foundation Trust, Centre for Anxiety Disorders and Trauma, London, UK. nick.1.grey@kcl.ac.uk.
Matthew HotopfDepartment of Psychological Medicine & Centre for Affective Disorders, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK. matthew.hotopf@kcl.ac.uk.
Paul MoranDepartment of Health Services and Population Research, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK. paul.moran@kcl.ac.uk.
Carmine M ParianteDepartment of Psychological Medicine & Centre for Affective Disorders, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK. carmine.pariante@kcl.ac.uk.
André TyleeDepartment of Health Services and Population Research, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK. andre.tylee@kcl.ac.uk.
Janet WingroveSouth London & Maudsley NHS Foundation Trust, Southwark Psychological Therapies Service, London, UK. janet.wingrove@slam.nhs.uk.
Allan H YoungDepartment of Psychological Medicine & Centre for Affective Disorders, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK. allan.young@kcl.ac.uk.
Anthony J CleareDepartment of Psychological Medicine & Centre for Affective Disorders, King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK. anthony.cleare@kcl.ac.uk.
King's College London · GBSouth London and Maudsley NHS Foundation Trust · GB

Funding

Medical Research Council G108/603Medical Research Council MR/J002739/1Medical Research Council MR/N029488/1Wellcome Trust
6 · The paper itself

Abstract

backgroundA substantial number of patients do not benefit from first line psychological therapies for the treatment of depression and anxiety. Currently, there are no clear predictors of treatment outcomes for these patients. The PROMPT project aims to establish an infrastructure platform for the identification of factors that predict outcomes following psychological treatment for depression and anxiety. Here we report on the first year of recruitment and describe the characteristics of our sample to date.

methodsOne hundred and forty-seven patients awaiting treatment within an Improving Access to Psychological Therapies (IAPT) service were recruited between February 2014 and February 2015 (representing 48 % of those eligible). Baseline assessments were conducted to collect information on a variety of clinical, psychological and social variables including a diagnostic interview using the Mini International Neuropsychiatric Interview (MINI).

resultsOur initial findings showed that over a third of our sample were not presenting to IAPT services for the first time, and 63 % had been allocated to receive higher intensity IAPT treatments. Approximately half (46 %) were taking prescribed psychotropic medication (most frequently antidepressants). Co-morbidity was common: 72 % of the sample met criteria for 2 or more current MINI diagnoses. Our initial data also indicated that 16 % met criteria for borderline personality disorder and 69 % were at high risk of personality disorder. Sixty-one percent scored above the screening threshold for bipolarity. Over half of participants (55 %) reported experiencing at least one stressful life event in the previous 12 months, whilst 67 % reported experiencing at least one form of childhood trauma.

conclusionsOur results to date highlight the complex nature of patients seen within an urban IAPT service, with high rates of psychiatric comorbidity, personality disorder, bipolarity and childhood trauma. Whilst there are significant challenges associated with researching IAPT populations, we have also confirmed the feasibility of undertaking such research.

Indexed as

Health Services AccessibilityAdolescentAdultAgedAnxiety DisordersCohort StudiesDepressive DisorderFemaleHumansLondonMaleMental DisordersMiddle AgedTreatment OutcomeYoung Adult

Identifiers

PMID26920578
PMCPMC4769576
OpenAlexW2275175808

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.