ArticleParasites & vectors2016
Analysis of esterase enzyme activity in adults of the major malaria vector Anopheles funestus.
Article in Parasites & vectors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
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- Eco-friendly bioactives from Nyctanthes arbor-tristis (L.) for targeted control of Aedes aegypti and Culex quinquefasciatus with reduced impact on Toxorhynchites splendens.Scientific reports · 2025Article
- Data-driven networking of global transcriptomics and male sexual development in the main malaria vector, Anopheles funestus.Scientific reports · 2023Article
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- Transcriptome-Based Identification of a FunctionalPathogens (Basel, Switzerland) · 2021Article
- The interaction between permethrin exposure and malaria infection affects the host-seeking behaviour of mosquitoes.Malaria journal · 2019Article
- Molecular and physiological analysis of Anopheles funestus swarms in Nchelenge, Zambia.Malaria journal · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnopheles funestus is a major vector of malaria in sub-Saharan Africa. In order to apply effective control measures against this vector, it is necessary to understand the underlying physiological factors that play a critical role in its development, reproduction, fertility and susceptibility to insecticides. One enzyme family involved in the above mentioned biological pathways is the esterases. The aim of this study was to analyse esterase activity levels at different ages during the life-span of adult Anopheles funestus Giles in order to better understand the complex biological processes in this species.
methodsIsoenzyme electrophoresis (IEE) was used to examine the esterase activity in laboratory colonised An. funestus adults aged between 2 h (h) and 30 days post eclosion as well as in wild An. funestus adults aged between 2 h and 15 days post eclosion. Esterase activity was quantified by densitometry analysis of the IEE gels. Esterases were classified according to their activity inhibition by organic phosphates, eserine sulphate and sulphydryl reagents.
resultsNine esterases IEE profiles were common to both the laboratory colonised and wild An. funestus adults. These esterases were further divided into acetylesterases, arylesterases, carboxylesterases and acetylcholinesterase. The activity level of certain specific esterases was primarily influenced by age and/or gender.
conclusionsThe information from this study contributes towards the general understanding of esterase enzyme activity variation in adults of a major malaria vector An. funestus. This variation likely carries physiological and adaptive significance and may influence specific characteristics, such as reproductive fitness and insecticide resistance that are epidemiologically important.
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