Evidence map›Paper›PMID 26920355›Full record

Trial reportMolecular imaging and biology2016

Repeatability of Radiomic Features in Non-Small-Cell Lung Cancer [(18)F]FDG-PET/CT Studies: Impact of Reconstruction and Delineation.

Floris H P van Velden, Gerbrand M Kramer, Virginie Frings, Ida A Nissen, Emma R Mulder, Adrianus J de Langen, Otto S Hoekstra, Egbert F Smit, Ronald Boellaard

Abstract readClinical Trial
In one paragraph

Trial report in Molecular imaging and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. EANM guideline on the role of 2-[European journal of nuclear medicine and molecular imaging · 2021
    Guideline
  5. Repeatability and Reproducibility of Radiomic Features: A Systematic Review.International journal of radiation oncology, biology, physics · 2018
    Pooled it
  6. Trial
  7. Robustness of Radiomic Features in [Molecular imaging and biology · 2016
    Trial
  8. Article
  9. Prognostic value of TMTV and Dmax calculated fromEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  10. Assessing Respiratory Motion Stability of NovelDiagnostics (Basel, Switzerland) · 2026
    Article
  11. Article
  12. Article
  13. Sureness of classification of breast cancers as pure ductal carcinomaJournal of medical imaging (Bellingham, Wash.) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Floris H P van VeldenDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, The Netherlands. f.h.p.van_velden@lumc.nl.
Gerbrand M KramerDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, The Netherlands.
Virginie FringsDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, The Netherlands.
Ida A NissenDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, The Netherlands.
Emma R MulderDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, The Netherlands.
Adrianus J de LangenDepartment of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands.
Otto S HoekstraDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, The Netherlands.
Egbert F SmitDepartment of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands.
Ronald BoellaardDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess (1) the repeatability and (2) the impact of reconstruction methods and delineation on the repeatability of 105 radiomic features in non-small-cell lung cancer (NSCLC) 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) positron emission tomorgraphy/computed tomography (PET/CT) studies. PROCEDURES: Eleven NSCLC patients received two baseline whole-body PET/CT scans. Each scan was reconstructed twice, once using the point spread function (PSF) and once complying with the European Association for Nuclear Medicine (EANM) guidelines for tumor PET imaging. Volumes of interest (n = 19) were delineated twice, once on PET and once on CT images.

resultsSixty-three features showed an intraclass correlation coefficient ≥ 0.90 independent of delineation or reconstruction. More features were sensitive to a change in delineation than to a change in reconstruction (25 and 3 features, respectively).

conclusionsThe majority of features in NSCLC [(18)F]FDG-PET/CT studies show a high level of repeatability that is similar or better compared to simple standardized uptake value measures.

Indexed as

Image Processing, Computer-AssistedPositron Emission Tomography Computed TomographyAgedCarcinoma, Non-Small-Cell LungDemographyFemaleFluorodeoxyglucose F18HumansLung NeoplasmsMaleMiddle AgedReproducibility of ResultsFluorodeoxyglucose F18Non-small-cell lung cancer (NSCLC)PET/CTRadiomicsRepeatabilityTracer uptake heterogeneity

Identifiers

PMID26920355
PMCPMC5010602

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.