ArticleeLife2016
Conditioned respiratory threat in the subdivisions of the human periaqueductal gray.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- Brief structured respiration practices enhance mood and reduce physiological arousal.Cell reports. Medicine · 2023Trial
- Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Trial
- Trial
- Iron-Sensitive MRI Reveals Individual Differences in Pain Modulation Rather Than Categorical Markers in Chronic Pain and Migraine.Pain research & management · 2026Article
- Asthma: Biomedical and Psychobiological Perspectives.Biopsychosocial science and medicine · 2025Review
- Non-zero risk of adverse psychological reactions induced by experimental dyspnoea studies in healthy volunteers: possible ethical implications.ERJ open research · 2025Article
- Lethal Interactions of neuronal networks in epilepsy mediated by both synaptic and volume transmission indicate approaches to prevention.Progress in neurobiology · 2025Review
- Seven Tesla Evidence for Columnar and Rostral-Caudal Organization of the Human Periaqueductal Gray Response in the Absence of Threat: A Working Memory Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Functional representation of trigeminal nociceptive input in the human periaqueductal gray.Science advances · 2024Article
- Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans.Nature communications · 2024Article
- Self-regulating arousal via pupil-based biofeedback.Nature human behaviour · 2024Article
- Whole-brain monosynaptic inputs to lateral periaqueductal gray glutamatergic neurons in mice.CNS neuroscience & therapeutics · 2023Article
- Review
- The effect of unpredictability on the perception of breathlessness: a narrative review.Frontiers in rehabilitation sciences · 2023Review
- Brainstem networks construct threat probability and prediction error from neuronal building blocks.Nature communications · 2022Article
- Ventrolateral periaqueductal gray matter integrative system of defense and antinociception.Pflugers Archiv : European journal of physiology · 2022Article
- A 7-Tesla MRI study of the periaqueductal gray: resting state and task activation under threat.Social cognitive and affective neuroscience · 2022Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The sensation of breathlessness is the most threatening symptom of respiratory disease. The different subdivisions of the midbrain periaqueductal gray (PAG) are intricately (and differentially) involved in integrating behavioural responses to threat in animals, while the PAG has previously only been considered as a single entity in human research. Here we investigate how these individual PAG columns are differently involved with respiratory threat. Eighteen healthy subjects were conditioned to associate shapes with certain or uncertain impending respiratory load, and scanned the following day during anticipation and application of inspiratory loading using 7 T functional MRI. We showed activity in the ventrolateral PAG (vlPAG) during anticipation of resistive loading, with activity in the lateral PAG (lPAG) during resistive loading, revealing spatially and temporally distinct functions within this structure. We propose that lPAG is involved with sensorimotor responses to breathlessness, while the vlPAG operates within the threat perception network for impending breathlessness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.