ArticleeLife2016
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 76 citations in OpenAlex.
- Striatal endocannabinoids drive one-shot learning.Nature neuroscience · 2026Article
- Irregular and bursty neuronal firing extend spike-timing dependent plasticity window to behavioral timescales.iScience · 2026Article
- An ultra low frequency spike timing dependent plasticity based approach for reducing alcohol drinking.Scientific reports · 2024Article
- Impact of Omega-3 on Endocannabinoid System Expression and Function, Enhancing Cognition and Behavior in Male Mice.Nutrients · 2024Article
- Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses.eLife · 2024Article
- The role of astrocytes from synaptic to non-synaptic plasticity.Frontiers in cellular neuroscience · 2024Review
- Sensory Reinforced Corticostriatal Plasticity.Current neuropharmacology · 2024Article
- Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning.PLoS computational biology · 2022Article
- Acute cannabinoids impair association learning via selectively enhancing synaptic transmission in striatonigral neurons.BMC biology · 2022Article
- 2-Arachidonoylglycerol mobilization following brief synaptic stimulation in the dorsal lateral striatum requires glutamatergic and cholinergic neurotransmission.Neuropharmacology · 2022Article
- Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids inFrontiers in synaptic neuroscience · 2022Article
- Presynaptic stochasticity improves energy efficiency and helps alleviate the stability-plasticity dilemma.eLife · 2021Article
- Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Receptor-Dependent and Independent Regulation of Voltage-Gated CaInternational journal of molecular sciences · 2021Review
- Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence.Biomedicines · 2021Article
- Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.PloS one · 2021Article
- Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction.Frontiers in immunology · 2021Review
- Dysfunction of the corticostriatal pathway in autism spectrum disorders.Journal of neuroscience research · 2020Review
- Lights on Endocannabinoid-Mediated Synaptic Potentiation.Frontiers in molecular neuroscience · 2020Review
- Engrams of Fast Learning.Frontiers in cellular neuroscience · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic plasticity is a cardinal cellular mechanism for learning and memory. The endocannabinoid (eCB) system has emerged as a pivotal pathway for synaptic plasticity because of its widely characterized ability to depress synaptic transmission on short- and long-term scales. Recent reports indicate that eCBs also mediate potentiation of the synapse. However, it is not known how eCB signaling may support bidirectionality. Here, we combined electrophysiology experiments with mathematical modeling to question the mechanisms of eCB bidirectionality in spike-timing dependent plasticity (STDP) at corticostriatal synapses. We demonstrate that STDP outcome is controlled by eCB levels and dynamics: prolonged and moderate levels of eCB lead to eCB-mediated long-term depression (eCB-tLTD) while short and large eCB transients produce eCB-mediated long-term potentiation (eCB-tLTP). Moreover, we show that eCB-tLTD requires active calcineurin whereas eCB-tLTP necessitates the activity of presynaptic PKA. Therefore, just like glutamate or GABA, eCB form a bidirectional system to encode learning and memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.