Evidence map›Paper›PMID 26920110›Full record

ReviewJournal of molecular biology2016

Noncoding RNAs: Regulators of the Mammalian Transcription Machinery.

Tess M Eidem, Jennifer F Kugel, James A Goodrich

Abstract readReview
In one paragraph

Review in Journal of molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. ncRNA Editing: Functional Characterization and Computational Resources.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  6. Article
  7. Article
  8. A novel intronic circular RNA circFGFR1Journal of translational medicine · 2023
    Article
  9. Review
  10. Review
  11. The Role of miR-128 in Neurodegenerative Diseases.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. mExperimental & molecular medicine · 2021
    Article
  17. Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Article
  19. Article
  20. Circular RNAs: Functions and Prospects in Glioma.Journal of molecular neuroscience : MN · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tess M EidemDepartment of Chemistry and Biochemistry, University of Colorado, 596 UCB, Boulder, CO 80309-0596, USA.
Jennifer F KugelDepartment of Chemistry and Biochemistry, University of Colorado, 596 UCB, Boulder, CO 80309-0596, USA. Electronic address: jennifer.kugel@colorado.edu.
James A GoodrichDepartment of Chemistry and Biochemistry, University of Colorado, 596 UCB, Boulder, CO 80309-0596, USA. Electronic address: james.goodrich@colorado.edu.
University of Colorado Boulder · US

Funding

Regulation of RNA polymerase ll by small RNAsR01GM068414 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI GOODRICH, JAMES · 2003 to 2018
$5.1M
NIGMS NIH HHS R01 GM068414
6 · The paper itself

Abstract

Transcription by RNA polymerase II (Pol II) is required to produce mRNAs and some noncoding RNAs (ncRNAs) within mammalian cells. This coordinated process is precisely regulated by multiple factors, including many recently discovered ncRNAs. In this perspective, we will discuss newly identified ncRNAs that facilitate DNA looping, regulate transcription factor binding, mediate promoter-proximal pausing of Pol II, and/or interact with Pol II to modulate transcription. Moreover, we will discuss new roles for ncRNAs, as well as a novel Pol II RNA-dependent RNA polymerase activity that regulates an ncRNA inhibitor of transcription. As the multifaceted nature of ncRNAs continues to be revealed, we believe that many more ncRNA species and functions will be discovered.

Indexed as

AnimalsDNAHumansMammalsPromoter Regions, GeneticRNA Polymerase IIRNA, UntranslatedTranscription FactorsTranscription, GeneticDNARNA Polymerase IIRNA, UntranslatedTranscription Factorscircular RNAsdivergent RNAsenhancer RNAsRNA polymerase IItethered RNAs

Identifiers

PMID26920110
PMCPMC4894004
OpenAlexW2279873413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.