ArticleCirculation. Cardiovascular imaging2016
Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function.
Article in Circulation. Cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Cardiovascular Changes in Menopause.Current cardiology reviews · 2021Pooled it
- A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics onInternational journal of molecular sciences · 2019Pooled it
- Metabolic and redox pathway dysregulation in HIV-associated coronary endothelial dysfunction.American journal of physiology. Heart and circulatory physiology · 2026Observational
- Metabolic and Redox Pathway Dysregulation in HIV-Associated Coronary Endothelial Dysfunction: Insights into Early-Phase HIV Vascular Dysfunction.bioRxiv : the preprint server for biology · 2025Article
- Endothelial Dysfunction in Youth-Onset Type 2 Diabetes: A Clinical Translational Study.Circulation research · 2024Observational
- Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals.American journal of physiology. Heart and circulatory physiology · 2023Article
- Vascular aging and cardiovascular disease: pathophysiology and measurement in the coronary arteries.Frontiers in cardiovascular medicine · 2023Review
- Is Vasospastic Coronary Disease More Common Than We Realize?JACC. Case reports · 2022Article
- Advances in Chemical Composition, Extraction Techniques, Analytical Methods, and Biological Activity ofMolecules (Basel, Switzerland) · 2022Review
- Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health.Frontiers in cardiovascular medicine · 2022Review
- Randomized Trial of Anti-inflammatory Medications and Coronary Endothelial Dysfunction in Patients With Stable Coronary Disease.Frontiers in cardiovascular medicine · 2021Article
- The Role of Multimodality Imaging in HIV-Associated Cardiomyopathy.Frontiers in cardiovascular medicine · 2021Review
- The Cardiovascular Stress Response as Early Life Marker of Cardiovascular Health: Applications in Population-Based Pediatric Studies-A Narrative Review.Pediatric cardiology · 2020Review
- Coronary vasomotion and exercise-induced adaptations in coronary artery disease patients: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Review
- Article
- Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI.Magnetic resonance in medicine · 2019Article
- Regional coronary endothelial dysfunction is related to the degree of local epicardial fat in people with HIV.Atherosclerosis · 2018Article
- Coronary Endothelial Dysfunction Is Associated With Elevated Serum PCSK9 Levels in People With HIV Independent of Low-Density Lipoprotein Cholesterol.Journal of the American Heart Association · 2018Article
- Coronary endothelial function is better in healthy premenopausal women than in healthy older postmenopausal women and men.PloS one · 2017Article
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9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNormal endothelial function is a measure of vascular health and dysfunction is a predictor of coronary events. Nitric oxide-mediated coronary artery endothelial function, as assessed by vasomotor reactivity during isometric handgrip exercise (IHE), was recently quantified noninvasively with magnetic resonance imaging (MRI). Because the internal mammary artery (IMA) is often visualized during coronary MRI, we propose the strategy of simultaneously assessing systemic and coronary endothelial function noninvasively by MRI during IHE. METHODS AND
resultsChanges in cross-sectional area and blood flow in the right coronary artery and the IMA in 25 patients with coronary artery disease and 26 healthy subjects during IHE were assessed using 3T MRI. In 8 healthy subjects, a nitric oxide synthase inhibitor was infused to evaluate the role of nitric oxide in the IMA-IHE response. Interobserver IMA-IHE reproducibility was good for cross-sectional area (R=0.91) and blood flow (R=0.91). In healthy subjects, cross-sectional area and blood flow of the IMA increased during IHE, and these responses were significantly attenuated by monomethyl-l-arginine (P<0.01 versus placebo). In patients with coronary artery disease, the right coronary artery did not dilate with IHE, and dilation of the IMA was less than that of the healthy subjects (P=0.01). The blood flow responses of both the right coronary artery and IMA to IHE were also significantly reduced in patients with coronary artery disease.
conclusionsMRI-detected IMA responses to IHE primarily reflect nitric oxide-dependent endothelial function and are reproducible and reduced in patients with coronary artery disease. Endothelial function in both coronary and systemic (IMA) arteries can now be measured noninvasively with the same imaging technique and promises novel insights into systemic and local factors affecting vascular health.
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