Evidence map›Paper›PMID 26919988›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

The impact of chemosensory and food-related changes in patients with advanced oesophagogastric cancer treated with capecitabine and oxaliplatin: a qualitative study.

Yfke C de Vries, Esther Helmich, Matty D A Karsten, Sanne Boesveldt, Renate M Winkels, Hanneke W M van Laarhoven

Open access · hybridAbstract read
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. What helps or hinders adult cancer patients in accepting dietary interventions during chemotherapy? A qualitative synthesis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  2. Experiences and requirements in nutritional management of patients with esophageal cancer: a systematic review and qualitative meta-synthesis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  3. Trial
  4. Testicular cancer patients undergoing cisplatin based chemotherapy exhibit temporary olfactory threshold scores changes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Trial
  5. Article
  6. Article
  7. Taste and Smell Alterations (TSAs) in Cancer Patients.Diseases (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Review
  10. Taste loss in cancer patients: clinicians' perceptions of educational materials and diagnostic tools.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  11. Article
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  17. Chemotherapy alters subjective senses of taste and smell but not dietary patterns in Japanese lung cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  18. Article
  19. Article
  20. Nutrition and taste and smell dysfunction.World journal of otorhinolaryngology - head and neck surgery · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yfke C de VriesTop Institute Food and Nutrition, P.O. Box 557, Wageningen, 6700 AN, The Netherlands. yfke.devries@wur.nl.
Esther HelmichCenter for Evidence-Based Education, Academic Medical Center, Amsterdam, The Netherlands.
Matty D A KarstenDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands.
Sanne BoesveldtDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands.
Renate M WinkelsDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands.
Hanneke W M van LaarhovenDepartment of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands.
Wageningen University & Research · NLAcademic Medical Center · NLFood & Nutrition · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChemosensory changes are frequently observed side effects of cytotoxic treatment and have an impact on daily life by altering food-related behaviour and daily practices. For oesophagogastric cancer patients, these changes can be particularly important as they may have specific needs with regard to eating, due to obstruction of the upper intestinal tract. The purpose of this study was to gain insight into the impact of chemosensory and food-related changes in oesophagogastric cancer patients undergoing chemotherapy and how this may influence the practical and social aspects of food-related behaviour of patients and their relatives.

methodsWe used a qualitative interview approach with a cross-sectional design using semi-structured interviews. Template analysis was used to analyse patients' experiences with and the impact of chemosensory changes on daily life. Thirteen advanced oesophagogastric cancer patients treated with capecitabine and oxaliplatin were included by convenience sampling, recruited from one academic hospital, and interviewed at home or in the hospital.

resultsThere was a large variation in the impact of chemosensory changes in oesophagogastric cancer (OGC) patients, though daily life was impacted substantially when chemosensory and/or food-related changes were experienced. Three main themes emerged from the interviews: altered food preferences, practical constraints in daily life, and impact on social functioning.

conclusionChemosensory and food-related changes significantly influenced food preferences and had practical and social consequences in daily life of patients and their relatives. Specific nutritional care for these patients should be directed towards enhancing food enjoyment and should take the specific needs, related to the location of the tumour, into account.

Indexed as

AgedAntineoplastic AgentsCapecitabineCross-Sectional StudiesEsophageal NeoplasmsFemaleFood PreferencesHumansMaleMiddle AgedOrganoplatinum CompoundsOxaliplatinQualitative ResearchStomach NeoplasmsAntineoplastic AgentsCapecitabineOrganoplatinum CompoundsOxaliplatinCancerChemotherapyFood preferencesSmellTaste

Identifiers

PMID26919988
PMCPMC4877431
OpenAlexW2281305229

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.