ArticleEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery2016
Positron Emission Tomography and Magnetic Resonance Imaging of Cellular Inflammation in Patients with Abdominal Aortic Aneurysms.
Article in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 51 citations in OpenAlex.
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- Multifunctional nanoparticles in abdominal aortic aneurysm management: from basic research to clinical transformation.Journal of nanobiotechnology · 2025Review
- Association between perivascular fat density on CT angiography and abdominal aortic aneurysm progression.BMC medical imaging · 2025Article
- Pilot first-in-human CCR2 PET/CT to detect abdominal aortic aneurysm wall instability.Theranostics · 2025Article
- Atherosclerotic cardiovascular disease in aging and the role of advanced cardiovascular imaging.NPJ cardiovascular health · 2024Review
- NINJ1 Facilitates Abdominal Aortic Aneurysm Formation via Blocking TLR4-ANXA2 Interaction and Enhancing Macrophage Infiltration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Abdominal Aortic Aneurysm and PET/CT: From Molecular Mechanisms to Potential Molecular Imaging Targets.Reviews in cardiovascular medicine · 2023Review
- Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice.Cell death & disease · 2022Article
- Iterative reconstruction incorporating background correction improves quantification of [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Prospect of positron emission tomography for abdominal aortic aneurysm risk stratification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Review
- Improved identification of abdominal aortic aneurysm using the Kernelized Expectation Maximization algorithm.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Iron Oxide Nanoparticles as TAdvanced materials (Deerfield Beach, Fla.) · 2021Review
- Nanoparticle-Assisted Diagnosis and Treatment for Abdominal Aortic Aneurysm.Frontiers in medicine · 2021Review
- Effect of endovascular therapy on the expression levels of serum T lymphocyte subsets, Notch1 and TACE proteins in patients with abdominal aortic aneurysm.American journal of translational research · 2021Article
- Greater aortic inflammation and calcification in abdominal aortic aneurysmal disease than atherosclerosis: a prospective matched cohort study.Open heart · 2020Article
- Predictions and insights for the abdominal aortic aneurysm.Journal of thoracic disease · 2018Article
- Role of PET/CT in the Evaluation of Aortic Disease.Chonnam medical journal · 2018Review
- Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection.Theranostics · 2018Article
- Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress: A Combined Clinical and Finite Element Study.Journal of cardiovascular translational research · 2017Observational
- MR/PET Imaging of the Cardiovascular System.JACC. Cardiovascular imaging · 2017Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesInflammation is critical in the pathogenesis of abdominal aortic aneurysm (AAA) disease. Combined (18)F-fludeoxyglucose ((18)F-FDG) positron emission tomography with computed tomography (PET-CT) and ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) are non-invasive methods of assessing tissue inflammation. The aim of this study was to compare these techniques in patients with AAA. MATERIALS AND
methodsFifteen patients with asymptomatic AAA with diameter 46 ± 7 mm underwent PET-CT with (18)F-FDG, and T2*-weighted MRI before and 24 hours after administration of USPIO. The PET-CT and MRI data were then co-registered. Standardised uptake values (SUVs) were calculated to measure (18)F-FDG activity, and USPIO uptake was determined using the change in R2*. Comparisons between the techniques were made using a quadrant analysis and a voxel-by-voxel evaluation.
resultsWhen all areas of the aneurysm were evaluated, there was a modest correlation between the SUV on PET-CT and the change in R2* on USPIO-enhanced MRI (n = 70,345 voxels; r = .30; p < .0001). Although regions of increased (18)F-FDG and USPIO uptake co-localised on occasion, this was infrequent (kappa statistic 0.074; 95% CI 0.026-0.122). (18)F-FDG activity was commonly focused in the shoulder region whereas USPIO uptake was more apparent in the main body of the aneurysm. Maximum SUV was lower in patients with mural USPIO uptake.
conclusionsBoth (18)F-FDG PET-CT and USPIO-MRI uptake identify vascular inflammation associated with AAA. Although they demonstrate a modest correlation, there are distinct differences in the pattern and distribution of uptake, suggesting a differential detection of macrophage glycolytic and phagocytic activity respectively.
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