Evidence map›Paper›PMID 26919685›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2016

Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors.

Jie Hao, Kenneth C K Cheng, Laura G Kruger, Lena Larsson, James V Sugai, Joerg Lahann, William V Giannobile

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Novel approaches for periodontal tissue engineering.Genesis (New York, N.Y. : 2000) · 2022
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. CVD Polymers for Devices and Device Fabrication.Advanced materials (Deerfield Beach, Fla.) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jie HaoPeriodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.
Kenneth C K ChengBiointerfaces Institute, Department of Materials Science and Engineering, B26-115S NCRC, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109-2800, USA.
Laura G KrugerPeriodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.
Lena LarssonPeriodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.
James V SugaiPeriodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.
Joerg LahannBiointerfaces Institute, Department of Chemical Engineering, Materials Science and Engineering, Biomedical Engineering, Macromolecular Science and Engineering, B10-A175 NCRC, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109-2800, USA.
William V GiannobileDepartment of Periodontics and Oral Medicine and Department of Biomedical Engineering, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.

Funding

GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUESR01DE013397 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIANNOBILE, WILLIAM V · 2000 to 2014
$4.0M
National Institutes of Health DE13397NIDCR NIH HHS R01 DE013397
6 · The paper itself

Abstract

Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functional proteins within defined regions of biomaterials to produce customizable structures for targeted tissue regeneration.

Indexed as

Genetic VectorsGene Transfer TechniquesAdenoviridaeAntibodies, ImmobilizedBiocompatible MaterialsCells, CulturedGenetic TherapyHumansIntercellular Signaling Peptides and ProteinsPeriodontal LigamentRegenerative MedicineWound HealingAntibodies, ImmobilizedBiocompatible MaterialsIntercellular Signaling Peptides and Proteinsbone morphogenetic proteinsdrug deliverygene transferplatelet-derived growth factorregenerative medicinetissue regeneration

Identifiers

PMID26919685
PMCPMC5687504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.