ArticlePloS one2016
Serum Biochemical Phenotypes in the Domestic Dog.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Investigation of Serum Neurofilament Light Chain as a Surrogate for Cerebrospinal Fluid Neurofilament Light Chain in Canine Cognitive Dysfunction Syndrome.Animals : an open access journal from MDPI · 2026Article
- Cohort profile of the first 2,000 canine enrolees in the Mars Petcare Biobank: demographic, hematologic and serum biochemistry results from March 2022 to December 2024.BMC veterinary research · 2026Article
- Plasma protein increase as a chronological aging factor in healthy toy poodles.Scientific reports · 2025Article
- Age-related changes in growth and fecal parameters, nutrient digestibility, hematology, and serum biochemistry of Beagle dogs.Journal of animal science and technology · 2025Article
- Article
- A blinded, randomized and controlled multicenter field study investigating the safety and efficacy of long-term use of enflicoxib in the treatment of naturally occurring osteoarthritis in client-owned dogs.Frontiers in veterinary science · 2024Article
- Secondary right atrial thrombosis in three dogs: Antithrombotics therapy and echocardiographic follow-up.Veterinary medicine and science · 2023Article
- Serum Analytes of American Mink (Neovison Vison) Challenged with Aleutian Mink Disease Virus.Animals : an open access journal from MDPI · 2022Article
- The effect of photobiomodulation therapy on the management of chronic idiopathic large-bowel diarrhea in dogs.Lasers in medical science · 2022Article
- Age, breed, sex and diet influence serum metabolite profiles of 2000 pet dogs.Royal Society open science · 2022Article
- Evaluation of Fermented Oat and Black Soldier Fly Larva as Food Ingredients in Senior Dog Diets.Animals : an open access journal from MDPI · 2021Article
- QimmeqHealth-thyroid status of Greenland sled dogs (Canis lupus familiaris borealis).Acta veterinaria Scandinavica · 2021Article
- Comparison of a human portable blood glucose meter and automated chemistry analyser for measurement of blood glucose concentrations in healthy dogs.Veterinary medicine and science · 2021Article
- The use of soluble fibre for the management of chronic idiopathic large-bowel diarrhoea in police working dogs.BMC veterinary research · 2021Article
- Association between vitamin D metabolites, vitamin D binding protein, and proteinuria in dogs.Journal of veterinary internal medicine · 2020Article
- Hematological and Biochemical Reference Intervals for 5 Adult Hunting Dog Breeds Using a Blood Donor Database.Animals : an open access journal from MDPI · 2020Article
- Urinalysis in Great Dane Puppies from Birth to 28 Days of Age.Animals : an open access journal from MDPI · 2020Article
- Article
- Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging.Frontiers in genetics · 2019Review
- Spectrophotometry and Ultracentrifugation for Measurement of Plasma Lipids in Dogs with Diabetes Mellitus.Journal of veterinary internal medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serum or plasma biochemical profile is essential in the diagnosis and monitoring of systemic disease in veterinary medicine, but current reference intervals typically take no account of breed-specific differences. Breed-specific hematological phenotypes have been documented in the domestic dog, but little has been published on serum biochemical phenotypes in this species. Serum biochemical profiles of dogs in which all measurements fell within the existing reference intervals were retrieved from a large veterinary database. Serum biochemical profiles from 3045 dogs were retrieved, of which 1495 had an accompanying normal glucose concentration. Sixty pure breeds plus a mixed breed control group were represented by at least 10 individuals. All analytes, except for sodium, chloride and glucose, showed variation with age. Total protein, globulin, potassium, chloride, creatinine, cholesterol, total bilirubin, ALT, CK, amylase, and lipase varied between sexes. Neutering status significantly impacted all analytes except albumin, sodium, calcium, urea, and glucose. Principal component analysis of serum biochemical data revealed 36 pure breeds with distinctive phenotypes. Furthermore, comparative analysis identified 23 breeds with significant differences from the mixed breed group in all biochemical analytes except urea and glucose. Eighteen breeds were identified by both principal component and comparative analysis. Tentative reference intervals were generated for breeds with a distinctive phenotype identified by comparative analysis and represented by at least 120 individuals. This is the first large-scale analysis of breed-specific serum biochemical phenotypes in the domestic dog and highlights potential genetic components of biochemical traits in this species.
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