Evidence map›Paper›PMID 26919426›Full record

ArticleCell2016

UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness.

Chitoku Toda, Jung Dae Kim, Daniela Impellizzeri, Salvatore Cuzzocrea, Zhong-Wu Liu, Sabrina Diano

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 3 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 3 syntheses or guidelines pooled it, 172 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  6. Article
  7. Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health.International journal of biological sciences · 2026
    Review
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  18. Determination of osteopontin in monitoring retinal damage in metabolic syndrome.International journal of experimental pathology · 2024
    Article
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  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Chitoku TodaProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA.
Jung Dae KimProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA.
Daniela ImpellizzeriProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA; Department of Biological and Environmental Sciences, University of Messina, Messina 98166, Italy.
Salvatore CuzzocreaProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA; Department of Biological and Environmental Sciences, University of Messina, Messina 98166, Italy.
Zhong-Wu LiuProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA.
Sabrina DianoProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA; Department of Neuroscience, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA; Section of Comparative Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut 06520, USA. Electronic address: sabrina.diano@yale.edu.
Yale University · USUniversity of Messina · IT

Funding

Mitochondrial Dynamics in VMH Neurons Control Glucose MetabolismR01DK107293 · NIDDK · YALE UNIVERSITY · PI DIANO, SABRINA · 2015 to 2022
$3.6M
Role of Peroxisome Proliferation in Leptin ResistanceR01DK097566 · NIDDK · YALE UNIVERSITY · PI DIANO, SABRINA · 2013 to 2020
$3.3M
NIDDK NIH HHS DK097566NIDDK NIH HHS DK107293NIDDK NIH HHS R01 DK097566NIDDK NIH HHS R01 DK107293
6 · The paper itself

Abstract

The ventromedial nucleus of the hypothalamus (VMH) plays a critical role in regulating systemic glucose homeostasis. How neurons in this brain area adapt to the changing metabolic environment to regulate circulating glucose levels is ill defined. Here, we show that glucose load results in mitochondrial fission and reduced reactive oxygen species in VMH neurons mediated by dynamin-related peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2). Probed by genetic manipulations and chemical-genetic control of VMH neuronal circuitry, we unmasked that this mitochondrial adaptation determines the size of the pool of glucose-excited neurons in the VMH and that this process regulates systemic glucose homeostasis. Thus, our data unmasked a critical cellular biological process controlled by mitochondrial dynamics in VMH regulation of systemic glucose homeostasis.

Indexed as

Mitochondrial DynamicsAnimalsCell NucleusDynaminsGene Knock-In TechniquesGlucoseHomeostasisIon ChannelsMiceMice, Inbred C57BLMice, KnockoutMitochondrial ProteinsNeuronsReactive Oxygen SpeciesUncoupling Protein 2Ventromedial Hypothalamic NucleusDnm1l protein, mouseDynaminsGlucoseIon ChannelsMitochondrial ProteinsReactive Oxygen SpeciesUcp2 protein, mouseUncoupling Protein 2

Identifiers

PMID26919426
PMCPMC4770556
OpenAlexW2278602690

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.