ArticleClinical oral implants research2017
FGF-2 promotes initial osseointegration and enhances stability of implants with low primary stability.
Article in Clinical oral implants research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The Impact of Implant Surface Modifications on the Osseointegration Process: An Overview.Cureus · 2025Review
- Review
- NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects.Frontiers in dental medicine · 2023Article
- Construction of functional surfaces for dental implants to enhance osseointegration.Frontiers in bioengineering and biotechnology · 2023Review
- Current and future trends in periodontal tissue engineering and bone regeneration.Plastic and aesthetic research · 2021Article
- A biomimetic engineered bone platform for advanced testing of prosthetic implants.Scientific reports · 2020Article
- Distinct Osteogenic Potentials of BMP-2 and FGF-2 in Extramedullary and Medullary Microenvironments.International journal of molecular sciences · 2020Article
- [Overview of animal researches about the effects of systemic drugs on implant osseointegration].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Review
- Development of a quantitative preclinical screening model for implant osseointegration in rat tail vertebra.Clinical oral investigations · 2019Article
- Cell Type Influences Local Delivery of Biomolecules from a Bioinspired Apatite Drug Delivery System.Materials (Basel, Switzerland) · 2018Article
- FGF-2 Gene Polymorphism in Osteoporosis among Guangxi's Zhuang Chinese.International journal of molecular sciences · 2017Article
- FGF-2 promotes initial osseointegration and enhances stability of implants with low primary stability.Clinical oral implants research · 2017Article
- Reducing the risk of impaired bone apposition to titanium screws with the use of fibroblast growth factor-2-apatite composite layer coating.Journal of orthopaedic surgery and research · 2017Article
- Role and influence of growth factors on early osseointegration in animal jaw bone: A meta-analysis.Journal of Indian Prosthodontic SocietyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to examine the effect of basic fibroblast growth factor (FGF-2) on osseointegration of dental implants with low primary stability in a beagle dog model. MATERIALS AND
methodsCustomized titanium implants that were designed to have low contact with the existing bone were installed into the edentulous mandible of beagle dogs. To degrade the primary stability of the implants, the diameters of the bone sockets exceeded the implant diameters. FGF-2 (0.3%) plus vehicle (hydroxypropyl cellulose) or vehicle alone was topically applied to the sockets in the FGF-2 and control groups, respectively. In Study 1, the new bone area and length of new bone-to-implant contact (BIC) were evaluated at 4, 8, and 12 weeks after installation using histomorphometry and scanning electron microscopy. In Study 2, the implant stability quotient (ISQ) values were sequentially measured for 16 weeks using an Osstell system.
resultsThe histomorphometric analysis revealed that the new bone area and length of BIC in the FGF-2 group were significantly larger than those in the control group at 4 weeks. Electron microscopic observation showed intimate contact between the mature lamellar bone and the implant surfaces, osseointegration, in both groups. The ISQ values in the FGF-2 group were significantly increased from 6 to 16 weeks compared with those in the control group.
conclusionsTaken together, our study demonstrates that FGF-2 promoted new bone formation around the dental implants and subsequent osseointegration, resulting in promotion of stability of implants with low primary stability.
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