ArticleInsect molecular biology2016
Assessment of tick antioxidant responses to exogenous oxidative stressors and insight into the role of catalase in the reproductive fitness of the Gulf Coast tick, Amblyomma maculatum.
Article in Insect molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- mGem: A tale as old as blood-do tick-borne pathogens exploit arthropod antioxidant defenses?mBio · 2026Review
- An Nrf2-Nup214 positive feedback loop sustains the antioxidant response and promotes microbial infection in ticks.bioRxiv : the preprint server for biology · 2026Article
- Blood feeding-induced transcriptomic changes in the hard tickFrontiers in insect science · 2026Article
- Sexual and regional differences in the microbiome and functional metagenome of the lone star tick, Amblyomma americanum.Animal microbiome · 2025Article
- Egg Protein Compositions over Embryonic Development inAnimals : an open access journal from MDPI · 2024Article
- A Proof-of-Concept Study to Develop a Peptide-Based Vaccine against Salmon Lice Infestation in Atlantic Salmon (Vaccines · 2024Article
- Article
- Circulating oxidative stress and acute phase protein levels in horses infested with ticks.Experimental & applied acarology · 2023Article
- PERK-mediated antioxidant response is key for pathogen persistence in ticks.bioRxiv : the preprint server for biology · 2023Article
- A Review on Digestive System ofInsects · 2023Review
- Purification, characterization, and enzyme kinetics of a glutathione S transferase from larvae of the camel tick Hyalomma dromedarii.Journal, genetic engineering & biotechnology · 2023Article
- Article
- Ambivalent Roles of Oxidative Stress in Triangular Relationships among Arthropod Vectors, Pathogens and Hosts.Antioxidants (Basel, Switzerland) · 2022Review
- Identification of microRNAs in the Lyme Disease VectorInternational journal of molecular sciences · 2022Article
- Occurrence, Density, and Transcriptomic Response of the Leafhopper Erythroneura sudra (Hemiptera: Cicadellidae) When Confronted With Different Fruit Tree Species.Journal of insect science (Online) · 2022Article
- Cationic Glycopolyelectrolytes for RNA Interference in Tick Cells.Biomacromolecules · 2022Article
- Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases.Frontiers in cellular and infection microbiology · 2022Review
- Hematophagy and tick-borne Rickettsial pathogen shape the microbial community structure and predicted functions within the tick vector,Frontiers in cellular and infection microbiology · 2022Article
- Recent advances in understanding tick and rickettsiae interactions.Parasite immunology · 2021Review
- Expression analysis of glutathione S-transferases and ferritins during the embryogenesis of the tickHeliyon · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
As obligate blood-sucking ectoparasites, to avoid tissue damage, ticks must neutralize the reactive oxygen species (ROS) generated from uptake and digestion of a bloodmeal. Consequently, ticks utilize a battery of antioxidant molecules, including catalase (CAT), an enzyme that converts hydrogen peroxide (H2 O2 ) into water and oxygen. Here, we investigated the tick antioxidant machinery by exogenous injection of sublethal doses of H2 O2 or paraquat. The relative transcript levels of selected Amblyomma maculatum antioxidant targets in tissues were determined by quantitative reverse transcriptase PCR following treatment. The results showed 2-16-fold increases in target antioxidant gene transcripts, signifying the ability of Am. maculatum to regulate its antioxidant machinery when exposed to increased ROS levels. Next, RNA interference was used to determine the functional role of CAT in haematophagy, redox homeostasis and reproductive fitness. CAT gene silencing was confirmed by transcript depletion within tick tissues; however, CAT knockdown alone did not interfere with tick haematophagy or phenotype, as confirmed by the resulting differential expression of antioxidant genes, thereby indicating an alternative mechanism for ROS control. Interestingly, double stranded RNA of CAT gene (dsCAT) and the CAT inhibitor, 3-aminotriazole, together reduced tick reproductive fitness via a marked reduction in egg mass and larval eclosion rates, highlighting a role for CAT in tick redox-homeostasis, making it a potential target for tick control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.