Evidence map›Paper›PMID 26918963›Full record

ArticlePloS one2016

Zinc Prevents Abdominal Aortic Aneurysm Formation by Induction of A20-Mediated Suppression of NF-κB Pathway.

Ya-Wei Yan, Jun Fan, Shu-Ling Bai, Wei-Jian Hou, Xiang Li, Hao Tong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Deubiquitinases as Regulators and Therapeutic Targets in Vascular Diseases.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ya-Wei YanDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, China.
Jun FanDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, China.
Shu-Ling BaiDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, China.
Wei-Jian HouDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, China.
Xiang LiDepartment of Cell Biology, College of Basic Medicine, China Medical University, Shenyang, China.
Hao TongDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammation and degradation of elastin are the main processes in the development of abdominal aortic aneurysm (AAA). Recent studies show that zinc has an anti-inflammatory effect. Based on these, zinc may render effective therapy for the treatment of the AAA. Currently, we want to investigate the effects of zinc on AAA progression and its related molecular mechanism. Rat AAA models were induced by periaortic application of CaCl2. AAA rats were treated by daily intraperitoneal injection of ZnSO4 or vehicle alone. The aorta segments were collected at 4 weeks after surgery. The primary rat aortic vascular smooth muscle cells (VSMCs) were stimulated with TNF-α alone or with ZnSO4 for 3 weeks. The results showed that zinc supplementation significantly suppressed the CaCl2-induced expansion of the abdominal aortic diameter, as well as a preservation of medial elastin fibers in the aortas. Zinc supplementation also obviously attenuated infiltration of the macrophages and lymphocytes in the aortas. In addition, zinc reduced MMP-2 and MMP-9 production in the aortas. Most importantly, zinc treatment significantly induced A20 expression, along with inhibition of the NF-κB canonical signaling pathway in vitro in VSMCs and in vivo in rat AAA. This study demonstrated, for the first time, that zinc supplementation could prevent the development of rat experimental AAA by induction of A20-mediated inhibition of the NF-κB canonical signaling pathway.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalAorta, AbdominalAortic Aneurysm, AbdominalCells, CulturedDisease Models, AnimalDNA-Binding ProteinsElastinI-kappa B KinaseI-kappa B ProteinsInflammationMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsMyocytes, Smooth MuscleAnti-Inflammatory Agents, Non-SteroidalDNA-Binding ProteinsElastinI-kappa B KinaseI-kappa B ProteinsMatrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsMmp2 protein, ratMmp9 protein, ratNF-kappa BNF-KappaB Inhibitor alphaNfkbia protein, ratTNFAIP3 protein, ratTumor Necrosis Factor alpha-Induced Protein 3Zinc Sulfate

Identifiers

PMID26918963
PMCPMC4769024
OpenAlexW2280169046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.