Evidence map›Paper›PMID 26918893›Full record

ArticleMagnetic resonance in medicine2017

Clinical translation of ferumoxytol-based vessel size imaging (VSI): Feasibility in a phase I oncology clinical trial population.

Jill Fredrickson, Natalie J Serkova, Shelby K Wyatt, Richard A D Carano, Andrea Pirzkall, Ina Rhee, Lee S Rosen, Alberto Bessudo, Colin Weekes, Alex de Crespigny

Open access · greenAbstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Advances in translational imaging of the microcirculation.Microcirculation (New York, N.Y. : 1994) · 2021
    Review
  3. Review
  4. Article
  5. Perspectives: MRI of angiogenesis.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Jill FredricksonClinical Imaging Group, Genentech, Inc., South San Francisco, California, USA.
Natalie J SerkovaDepartment of Anesthesiology, University of Colorado Cancer Center, Aurora, Colorado, USA.
Shelby K WyattDepartment of Biomedical Imaging, Genentech, Inc., South San Francisco, California, USA.
Richard A D CaranoDepartment of Biomedical Imaging, Genentech, Inc., South San Francisco, California, USA.
Andrea PirzkallOncology Clinical Development, Genentech, Inc., South San Francisco, California, USA.
Ina RheeOncology Clinical Development, Genentech, Inc., South San Francisco, California, USA.
Lee S RosenDepartment of Medicine, Division of Hematology and Oncology, UCLA, Santa Monica, California, USA.
Alberto BessudoSan Diego Pacific Oncology Hematology Associates Inc., Encinitas, California, USA.
Colin WeekesDepartment of Medical Oncology, University of Colorado Cancer Center, Aurora, Colorado, USA.
Alex de CrespignyClinical Imaging Group, Genentech, Inc., South San Francisco, California, USA.
Gene Therapy Laboratory · FRLaboratoire d’Imagerie Biomédicale · FRUniversity of Colorado Cancer Center · USColorado Permanente Medical Group · USPacific Eye Associates · USUniversity of Santa Monica · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
NCI NIH HHS P30 CA046934
6 · The paper itself

Abstract

purposeTo assess the feasibility of acquiring vessel size imaging (VSI) metrics using ferumoxytol injections and stock pulse sequences in a multicenter Phase I trial of a novel therapy in patients with advanced metastatic disease.

methodsScans were acquired before, immediately after, and 48 h after injection, at screening and after 2 weeks of treatment. ΔR

resultsR

conclusionClinical ferumoxytol-based VSI is feasible using standard MRI techniques in a multicenter study of patients with lesions outside of the brain. Ferumoxytol accumulation in the liver does not preclude measurement of VSI parameters in liver metastases. Magn Reson Med 77:814-825, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

AnimalsContrast MediaFerrosoferric OxideHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMiceMice, NudeNeoplasmsNeoplasms, ExperimentalContrast MediaFerrosoferric OxideangiogenesisDCE-MRItumorUSPIOvessel sizeVSI

Identifiers

PMID26918893
PMCPMC5677523
OpenAlexW2285627011

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.