Evidence map›Paper›PMID 26918830›Full record

SynthesisOncotarget2016

The effect of neuraxial anesthesia on cancer recurrence and survival after cancer surgery: an updated meta-analysis.

Meilin Weng, Wankun Chen, Wenting Hou, Lihong Li, Ming Ding, Changhong Miao

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
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  8. Article
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  15. Local anesthetics elicit immune-dependent anticancer effects.Journal for immunotherapy of cancer · 2022
    Article
  16. Article
  17. Review
  18. Anesthesia and Oncology: Friend or Foe?Frontiers in oncology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Meilin WengDepartment of Anesthesiology, Fudan University Shanghai Cancer Centre, Department of Oncology, Shanghai Medical College Fudan University, Shanghai, China.
Wankun ChenDepartment of Anesthesiology, Fudan University Shanghai Cancer Centre, Department of Oncology, Shanghai Medical College Fudan University, Shanghai, China.
Wenting HouDepartment of Anesthesiology, Fudan University Shanghai Cancer Centre, Department of Oncology, Shanghai Medical College Fudan University, Shanghai, China.
Lihong LiDepartment of Anesthesiology, Fudan University Shanghai Cancer Centre, Department of Oncology, Shanghai Medical College Fudan University, Shanghai, China.
Ming DingDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Changhong MiaoDepartment of Anesthesiology, Fudan University Shanghai Cancer Centre, Department of Oncology, Shanghai Medical College Fudan University, Shanghai, China.
Fudan University Shanghai Cancer Center · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several animal and observational studies have evaluated the effects of neuraxial anesthesia on the recurrence and survival of cancer surgery; studies reported benefit, whereas others did not. To provide further evidence that neuraxial anesthesia(combined with or without general anesthesia (GA))may be associated with reduced cancer recurrence and long-term survival after cancer surgery, we conducted this meta-analysis. A total of 21 studies were identified and analyzed, based on searches conducted using PubMed, Web of Science, EMBASE database and the Cochrane Database of Systematic Reviews. After data abstraction, adjusted hazard ratios (HR) with 95% confidence intervals (CIs) were used to assess the impact of neuraxial anesthesia (combined with or without GA) and GA on oncological outcomes after cancer surgery. For overall survival (OS), a potential association between neuraxial anesthesia and improved OS (HR 0.853, CI 0.741-0.981, P = 0.026, the random-effects model) was observed compared with GA. Specifically, we found a positive association between neuraxial anesthesia and improved OS in colorectal cancer (HR 0.653, CI 0.430-0.991, P = 0.045, the random-effects model). For recurrence-free survival (RFS), a significant association between neuraxial anesthesia and improved RFS (HR 0.846, CI 0.718-0.998, P = 0.047, the random-effects model) was detected compared with GA. Our meta-analysis suggests that neuraxial anesthesia may be associated with improved OS in patients with cancer surgery, especially for those patients with colorectal cancer. It also supports a potential association between neuraxial anesthesia and a reduced risk of cancer recurrence. More prospective studies are needed to elucidate whether the association between neuraxial use and survival is causative.

Indexed as

Anesthesia, GeneralHumansNeoplasm Recurrence, LocalNeoplasmsPrognosisSurvival Ratecancer outcomecancer recurrencegeneral anesthesianeuraxial anesthesiasurvival

Identifiers

PMID26918830
PMCPMC4924785
OpenAlexW2303477122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.