ArticleHuman brain mapping2016
The implication of frontostriatal circuits in young smokers: A resting-state study.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Relating Functional Connectivity and Alcohol Use Disorder: A Systematic Review and Derivation of Relevance Maps for Regions and Connections.Human brain mapping · 2025Pooled it
- Brain network dysfunctions in addiction: a meta-analysis of resting-state functional connectivity.Translational psychiatry · 2022Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Connectivity-Based Real-Time Functional Magnetic Resonance Imaging Neurofeedback in Nicotine Users: Mechanistic and Clinical Effects of Regulating a Meta-Analytically Defined Target Network in a Double-Blind Controlled Trial.Human brain mapping · 2024Trial
- Sex differences in tobacco smokers: Executive control network and frontostriatal connectivity.Drug and alcohol dependence · 2019Trial
- Functional network connectivity predicts treatment outcome during treatment of nicotine use disorder.Psychiatry research. Neuroimaging · 2017Trial
- Altered Topological Properties of White-Matter Functional Networks in Young Smokers.Addiction biology · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Beyond pain relief: the effects of chronic opioid use on brain structure and function in diabetic neuropathy-a multimodal neuroimaging study.Diabetologia · 2025Article
- Tobacco Smoking Functional Networks: A Whole-Brain Connectome Analysis in 24 539 Individuals.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Regulation of craving and underlying resting-state neural circuitry predict hazard of smoking lapse.Translational psychiatry · 2025Article
- Characteristic of cerebral hemodynamics and functional connectivity in patients with neuropathic pain after spinal cord injury: an exploratory study.Frontiers in neuroscience · 2025Article
- Resting-state fNIRS reveals changes in prefrontal cortex functional connectivity during TENS in patients with chronic pain.Scientific reports · 2024Article
- Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Dual roles of the amygdala-hippocampus circuit in the regulation of rapid eye movement sleep and depression symptoms by repetitive transcranial magnetic stimulation in patients with insomnia.General psychiatry · 2024Article
- Changes in aspartate metabolism in the medial-prefrontal cortex of nicotine addicts based on J-edited magnetic resonance spectroscopy.Human brain mapping · 2023Article
- Lifestyle risks associated with brain functional connectivity and structure.Human brain mapping · 2023Article
- Connectome-based predictive modeling of smoking severity using individualized structural covariance network in smokers.Frontiers in neuroscience · 2023Article
- Implications of neuroimaging findings in addiction.Psychoradiology · 2023Review
- Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The critical roles of frontostriatal circuits had been revealed in addiction. With regard to young smokers, the implication of frontostriatal circuits resting-state functional connectivity (RSFC) in smoking behaviors and cognitive control deficits remains unclear. In this study, the volume of striatum subsets, i.e., caudate, putamen, and nucleus accumbens, and corresponding RSFC differences were investigated between young smokers (n1 = 60) and nonsmokers (n2 = 60), which were then correlated with cigarette smoking measures, such as pack_years-cumulative effect of smoking, Fagerström Test for Nicotine Dependence (FTND)-severity of nicotine addiction, Questionnaire on Smoking Urges (QSU)-craving state, and Stroop task performances. Additionally, mediation analysis was carried out to test whether the frontostriatal RSFC mediates the relationship between striatum morphometry and cognitive control behaviors in young smokers when applicable. We revealed increased volume of right caudate and reduced RSFC between caudate and dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex in young smokers. Significant positive correlation between right caudate volume and QSU as well as negative correlation between anterior cingulate cortex-right caudate RSFC and FTND were detected in young smokers. More importantly, DLPFC-caudate RSFC strength mediated the relationship between caudate volume and incongruent errors during Stroop task in young smokers. Our results demonstrated that young smokers showed abnormal interactions within frontostriatal circuits, which were associated with smoking behaviors and cognitive control impairments. It is hoped that our study focusing on frontostriatal circuits could provide new insights into the neural correlates and potential novel therapeutic targets for treatment of young smokers. Hum Brain Mapp 37:2013-2026, 2016. © 2016 Wiley Periodicals, Inc.
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