ArticleThe Journal of physiology2016
Time-invariant feed-forward inhibition of Purkinje cells in the cerebellar cortex in vivo.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Behavioral correlates of Purkinje cell ensemble covariance.Nature communications · 2026Article
- Purkinje Cell Collaterals Preferentially Target a Subtype of Molecular Layer Interneuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.Research square · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.eLife · 2024Article
- Cerebellar interneurons control fear memory consolidation via learning-induced HCN plasticity.Cell reports · 2023Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.bioRxiv : the preprint server for biology · 2023Article
- Basket to Purkinje Cell Inhibitory Ephaptic Coupling Is Abolished in Episodic Ataxia Type 1.Cells · 2023Article
- Cerebellar molecular layer interneurons are dispensable for cued and contextual fear conditioning.Scientific reports · 2020Article
- Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex.eLife · 2020Article
- Multiple signals evoked by unisensory stimulation converge onto cerebellar granule and Purkinje cells in mice.Communications biology · 2020Article
- Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo.Cell reports · 2020Article
- Article
- Simulation of a Human-Scale Cerebellar Network Model on the K Computer.Frontiers in neuroinformatics · 2020Article
- Inferring and validating mechanistic models of neural microcircuits based on spike-train data.Nature communications · 2019Article
- Article
- Resting-State Neural Firing Rate Is Linked to Cardiac-Cycle Duration in the Human Cingulate and Parahippocampal Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Short-Term Plasticity Combines with Excitation-Inhibition Balance to Expand Cerebellar Purkinje Cell Dynamic Range.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- How does transient signaling input affect the spike timing of postsynaptic neuron near the threshold regime: an analytical study.Journal of computational neuroscience · 2018Article
- Impaired Motor Coordination and Learning in Mice Lacking Anoctamin 2 Calcium-Gated Chloride Channels.Cerebellum (London, England) · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsWe performed extracellular recording of pairs of interneuron-Purkinje cells in vivo. A single interneuron produces a substantial, short-lasting, inhibition of Purkinje cells. Feed-forward inhibition is associated with characteristic asymmetric cross-correlograms. In vivo, Purkinje cell spikes only depend on the most recent synaptic activity. ABSTRACT: Cerebellar molecular layer interneurons are considered to control the firing rate and spike timing of Purkinje cells. However, interactions between these cell types are largely unexplored in vivo. Using tetrodes, we performed simultaneous extracellular recordings of neighbouring Purkinje cells and molecular layer interneurons, presumably basket cells, in adult rats in vivo. The high levels of afferent synaptic activity encountered in vivo yield irregular spiking and reveal discharge patterns characteristic of feed-forward inhibition, thus suggesting an overlap of the afferent excitatory inputs between Purkinje cells and basket cells. Under conditions of intense background synaptic inputs, interneuron spikes exert a short-lasting inhibitory effect, delaying the following Purkinje cell spike by an amount remarkably independent of the Purkinje cell firing cycle. This effect can be explained by the short memory time of the Purkinje cell potential as a result of the intense incoming synaptic activity. Finally, we found little evidence for any involvement of the interneurons that we recorded with the cerebellar high-frequency oscillations promoting Purkinje cell synchrony. The rapid interactions between interneurons and Purkinje cells might be of particular importance in fine motor control because the inhibitory action of interneurons on Purkinje cells leads to deep cerebellar nuclear disinhibition and hence increased cerebellar output.
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