ArticleHuman brain mapping2016
Hippocampal gray matter volume in bilateral vestibular failure.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Reduced Vestibular Function is Associated With Cortical Surface Shape Changes in the Frontal Cortex.Human brain mapping · 2025Article
- Reduced Vestibular Function is Associated with Cortical Surface Shape Changes in the Frontal Cortex.medRxiv : the preprint server for health sciences · 2024Article
- Postural motion perception during vestibular stimulation depends on the motion perception threshold in persistent postural-perceptual dizziness.Journal of neurology · 2024Article
- Visual and vestibular motion perception in persistent postural-perceptual dizziness (PPPD).Journal of neurology · 2024Article
- Vestibular-evoked myogenic potential abnormalities in Parkinson's disease with freezing of gait.Journal of neurology · 2024Article
- Executive functions in patients with bilateral and unilateral peripheral vestibular dysfunction.Journal of neurology · 2024Article
- Vestibular Function is Associated with Prefrontal and Sensorimotor Cortical Gray Matter Volumes in a Cross-Sectional Study of Healthy, Older Adults.Aperture neuro · 2024Article
- Does path integration contribute to human navigation in large-scale space?Psychonomic bulletin & review · 2023Review
- Normal visuospatial function in unilateral vestibulopathy: on the challenge of group differences within normal reference data.Frontiers in neurology · 2023Article
- Functional and anatomical alterations in bilateral vestibulopathy: A multimodal neuroimaging study and clinical correlation.Frontiers in neurology · 2023Article
- Interpreting the meaning of changes in hippocampal volume associated with vestibular loss.Frontiers in integrative neuroscience · 2023Article
- Navigation strategies in patients with vestibular loss tested in a virtual reality T-maze.Journal of neurology · 2022Article
- Olfactory, Auditory, and Vestibular Performance: Multisensory Impairment Is Significantly Associated With Incident Cognitive Impairment.Frontiers in neurology · 2022Article
- The Effect of Galvanic Vestibular Stimulation on Visuospatial Cognition in an Incomplete Bilateral Vestibular Deafferentation Mouse Model.Frontiers in neurology · 2022Article
- Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact.Life (Basel, Switzerland) · 2021Article
- Linking Vestibular Function and Subcortical Gray Matter Volume Changes in a Longitudinal Study of Aging Adults.Aperture neuro · 2021Article
- Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space.Scientific reports · 2021Article
- The Cognitive-Vestibular Compensation Hypothesis: How Cognitive Impairments Might Be the Cost of Coping With Compensation.Frontiers in human neuroscience · 2021Article
- Cognitive functions in acute unilateral vestibular loss.Journal of neurology · 2020Article
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Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bilateral vestibular failure (BVF) is a severe chronic disorder of the labyrinth or the eighth cranial nerve characterized by unsteadiness of gait and disabling oscillopsia during head movements. According to animal data, vestibular input to the hippocampus is proposed to contribute to spatial memory and spatial navigation. Except for one seminal study showing the association of impaired spatial navigation and hippocampal atrophy, patient data in BVF are lacking. Therefore, we performed a voxel-wise comparison of the hippocampal gray matter volume (GMV) in a clinically representative sample of 27 patients with incomplete BVF and 29 age- and gender-matched healthy controls to test the hypothesis of hippocampal atrophy in BVF. Although the two groups did not generally differ in their hippocampal GMV, a reduction of GMV in the bilateral hippocampal CA3 region was significantly correlated with increased vestibulopathy-related clinical impairment. We propose that GMV reduction in the hippocampus of BVF patients is related to the severity of vestibular-induced disability which is in line with combined hippocampal atrophy and disorders of spatial navigation in complete vestibular deafferentation due to bilateral nerve section. Clinically, however, the most frequent etiologies of BVF cause incomplete lesions. Accordingly, hippocampus atrophy and deficits in spatial navigation occur possibly less frequently than previously suspected. Hum Brain Mapp 37:1998-2006, 2016. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.